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Showing 1–3 of 3 results
Advanced filters: Author: Gururaj Rao Kidiyoor Clear advanced filters

  • During cell migration, cells are polarized with distinct front vs. rear regions but whether and how polarity is transmitted to the nucleus is unclear. Here the authors show that frontally-biased endoplasmic reticulum and the nuclear membrane protein Emerin contribute to front-rear nuclear cell polarity.

    • Paulina Nastały
    • Divya Purushothaman
    • Paolo Maiuri
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • The nucleus is a mechanically stiff organelle of the cell and the DNA damage response protein ATR can localize to the nuclear envelope upon mechanical stress. Here, the authors show that ATR may contribute to the integrity of the nuclear envelope and may play a role in cell migration.

    • Gururaj Rao Kidiyoor
    • Qingsen Li
    • Marco Foiani
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Nuclear shape fluctuations during the cell cycle suggest a mechanical link between chromosome condensation and nuclear envelope breakdown during mitosis. Initially fluctuations are symmetric, but in the late G2 phase, they become inward and align with the condensing chromatin.

    • Viola Introini
    • Gururaj Rao Kidiyoor
    • Marco Cosentino Lagomarsino
    ResearchOpen Access
    Communications Biology
    Volume: 6, P: 1-11