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Showing 1–6 of 6 results
Advanced filters: Author: Gustavo Fenalti Clear advanced filters

  • CD47 is a transmembrane receptor involved in the regulation of various signalling pathways and a promising target for immuno-oncology therapeutics. Here, the authors present the crystal structure of full-length human CD47 and provide insights into the molecular mechanism of CD47-mediated signalling.

    • Gustavo Fenalti
    • Nicolas Villanueva
    • Kandasamy Hariharan
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • The 1.8 Å high-resolution X-ray crystal structure of the human δ-opioid receptor is presented, with site-directed mutagenesis and functional studies revealing a crucial role for a sodium ion in mediating allosteric control in this receptor.

    • Gustavo Fenalti
    • Patrick M. Giguere
    • Raymond C. Stevens
    Research
    Nature
    Volume: 506, P: 191-196

  • The X-ray crystal structure of the human P2Y12 receptor, which regulates platelet activation and thrombus formation, is solved in complex with an antithrombotic drug, providing insights for the development of new drugs.

    • Kaihua Zhang
    • Jin Zhang
    • Qiang Zhao
    Research
    Nature
    Volume: 509, P: 115-118

  • Serial femtosecond crystallography of the human δ-opioid receptor in complex with an endomorphin-derived peptide reveals interactions that are important for understanding the pharmacology of opioid peptides and developing analgesics with reduced side effects.

    • Gustavo Fenalti
    • Nadia A Zatsepin
    • Vadim Cherezov
    Research
    Nature Structural & Molecular Biology
    Volume: 22, P: 265-268