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Q586B2 is a crucial virulence factor during the early stages of Trypanosoma brucei infection that is conserved amongst trypanosomatids

Sleeping sickness caused by African trypanosome parasites induces a chronic, and potentially lethal, infection in humans. Here, the authors uncover a conserved protein, Q586B2, playing an important regulatory role in Trypanosomatid infection establishment.

Benoit Stijlemans
Patrick De Baetselier
Carl De Trez
ResearchOpen Access27 Feb 2024
Nature Communications

Volume: 15, P: 1-18
Prostaglandin Production and Zinc Depletion in Human Pregnancy

Karen Simmer
Neville A Punchard
Richard P H Thompson
Research01 Jul 1985
Pediatric Research

Volume: 19, P: 697-700
Impact of pulmonary African trypanosomes on the immunology and function of the lung

A number of human African trypanosomiasis, or sleeping sickness, patients suffer from respiratory symptoms commonly attributed to cardiac insufficiency. Here, the authors characterise the role of pulmonary Trypanosoma brucei in respiratory infection.

Dorien Mabille
Laura Dirkx
Guy Caljon
ResearchOpen Access18 Nov 2022
Nature Communications

Volume: 13, P: 1-18
Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness

Trypanosoma brucei relies on uptake and conversion of purines from the host, which constitutes a potential drug target. Here, Hulpia et al. combine structural elements from known trypanocidal nucleoside analogues and develop a potent trypanocide with curative activity in animal models of acute and late stage sleeping sickness.

Fabian Hulpia
Dorien Mabille
Serge Van Calenbergh
ResearchOpen Access05 Dec 2019
Nature Communications

Volume: 10, P: 1-11
Past and future spread of the arbovirus vectors Aedes aegypti and Aedes albopictus

Statistical mapping techniques provide insights into the spread of two key arbovirus vectors in Europe and the United States, and predict the future distributions of both mosquitoes in response to accelerating urbanization, connectivity and climate change.

Moritz U. G. Kraemer
Robert C. Reiner Jr
Nick Golding
ResearchOpen Access04 Mar 2019
Nature Microbiology

Volume: 4, P: 854-863
Updated vaccine protects against SARS-CoV-2 variants including Omicron (B.1.1.529) and prevents transmission in hamsters

Currently licensed COVID-19 vaccines are based on antigen sequences of early SARS-CoV-2 isolates, despite the prevalence of variants of concerns escaping vaccine-mediated protection. Using their updated yellow fever 17D vectored candidate, here, authors assess neutralising antibody responses against variants of concern, and demonstrate protection and reduced transmission in a hamster model.

Sapna Sharma
Thomas Vercruysse
Kai Dallmeier
ResearchOpen Access04 Nov 2022
Nature Communications

Volume: 13, P: 1-11
Publisher Correction: Past and future spread of the arbovirus vectors Aedes aegypti and Aedes albopictus

Moritz U. G. Kraemer
Robert C. Reiner Jr
Nick Golding
Amendments and CorrectionsOpen Access21 Mar 2019
Nature Microbiology

Volume: 4, P: 900
Publisher Correction: Past and future spread of the arbovirus vectors Aedes aegypti and Aedes albopictus

Moritz U. G. Kraemer
Robert C. Reiner Jr
Nick Golding
Amendments and CorrectionsOpen Access08 Apr 2019
Nature Microbiology

Volume: 4, P: 901
The global compendium of Aedes aegypti and Ae. albopictus occurrence

Moritz U. G. Kraemer
Marianne E. Sinka
Simon I. Hay
ResearchOpen Access07 Jul 2015
Scientific Data

Volume: 2, P: 1-8
Assessment of infant outgrowth of cow’s milk allergy in relation to the faecal microbiome and metaproteome

Diana M. Hendrickx
Ran An
Clara Belzer
ResearchOpen Access25 Jul 2023
Scientific Reports

Volume: 13, P: 1-18
Long-term hematopoietic stem cells as a parasite niche during treatment failure in visceral leishmaniasis

Long-term hematopoietic stem cells may act as protective niches for the Leishmania parasite, potentially contributing to treatment failure in cases of visceral leishmaniasis.

Laura Dirkx
Sarah Hendrickx
Guy Caljon
ResearchOpen Access25 Jun 2022
Communications Biology

Volume: 5, P: 1-15
IL-24 contributes to skin inflammation in Para-Phenylenediamine-induced contact hypersensitivity

Astrid B. Van Belle
Perrine M. Cochez
Laure Dumoutier
ResearchOpen Access12 Feb 2019
Scientific Reports

Volume: 9, P: 1-11
Involvement of T-cell receptor-β alterations in the development of otosclerosis linked to OTSC2

I Schrauwen
K Venken
G Van Camp
Research25 Feb 2010
Genes & Immunity

Volume: 11, P: 246-253

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Q586B2 is a crucial virulence factor during the early stages of Trypanosoma brucei infection that is conserved amongst trypanosomatids

Prostaglandin Production and Zinc Depletion in Human Pregnancy

Impact of pulmonary African trypanosomes on the immunology and function of the lung

Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness

Past and future spread of the arbovirus vectors Aedes aegypti and Aedes albopictus

Updated vaccine protects against SARS-CoV-2 variants including Omicron (B.1.1.529) and prevents transmission in hamsters

Publisher Correction: Past and future spread of the arbovirus vectors Aedes aegypti and Aedes albopictus

Publisher Correction: Past and future spread of the arbovirus vectors Aedes aegypti and Aedes albopictus

The global compendium of Aedes aegypti and Ae. albopictus occurrence

Assessment of infant outgrowth of cow’s milk allergy in relation to the faecal microbiome and metaproteome

Long-term hematopoietic stem cells as a parasite niche during treatment failure in visceral leishmaniasis

IL-24 contributes to skin inflammation in Para-Phenylenediamine-induced contact hypersensitivity

Involvement of T-cell receptor-β alterations in the development of otosclerosis linked to OTSC2

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