Little is known on how solid tumours overcome growth inhibitory signals within its hypoxic microenvironment. Here Henze et al.show that oxygen sensor PHD3 is frequently lost in gliomas, and that this loss hyperactivates EGFR signaling to sustain tumour cell proliferation and survival in hypoxia.
- Anne-Theres Henze
- Boyan K. Garvalov
- Till Acker
