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How directional information is integrated into classic place coding and landmark vector coding within the hippocampus remain not fully understood. Here authors show that, both place cells and landmark vector cells (LVCs) receive identical directional inputs, yet the firing fields of place cells and LVCs rotated by similar degrees relative to the center of the environment and relative to the nearby landmark, respectively.

The analysis of radial velocity variations of O-type stars in the Small Magellanic Cloud reveals a large fraction of close binaries, suggesting that binary physics also plays a prominent role in the low-metallicity environment of the distant Universe.

Human papillomavirus (HPV) DNA testing is the preferred method for cervical cancer screening, but existing tests are inaccessible for resource-limited settings. Here, authors develop a low-cost, simple HPV DNA assay suitable for bedside testing and demonstrate strong performance in Mozambique.

Electrical transport measurements of magic-angle twisted trilayer graphene are presented.

The role of water in the kinetics of the self-assembly process of amphiphilic peptides still remains unknown. Sankaranarayanan et al. have shown through computational study that water has a dual nature when dictating the mechanism and dynamics of self-assembly of peptide amphiphiles.

Halving average drainage depths in agricultural peatlands could reduce greenhouse gas emissions by the equivalent of 1 per cent of all anthropogenic emissions.

Chromophore supramolecular assemblies have long been studied for their exotic photophysical properties arising from their local geometry and long-range sensitive excitonic couplings. Now a high-resolution structure of a model nanotubular system has revealed a uniform brick-layer molecular arrangement and a non-biological supramolecular motif—interlocking sulfonates—enabling clear understanding of supramolecular structure–excitonic property relationships.

Glutamine synthetase is the only enzyme that synthesizes glutamine in mammals. In vivo metabolomics showed that glutamine synthetase utilizes methylamine to produce N⁵-methylglutamine, whose levels correlate with tumor burden in a β+catenin+mutant liver cancer model.

Unimolecular integration of NMDA receptor antagonism with GLP-1 receptor agonism effectively reverses obesity, hyperglycaemia and dyslipidaemia in rodent models of metabolic disease.

Izar and colleagues demonstrate that loss of Pip4k2c in melanoma cells promotes liver metastatic tropism driven by PI3K-AKT pathway activation in the insulin-rich liver milieu, which can be abrogated by inhibition of SGLT2 or a ketogenic diet.

Moiré superlattices offer a rich platform fort the study of correlated and topological phases. Here, by using low-temperature magneto-transport measurements, the authors demonstrate electric-field induced switching between Chern states in twisted double-layer graphene in the Hofstadter regime.

Temporal multi-omic analysis of tissues from rats undergoing up to eight weeks of endurance exercise training reveals widespread shared, tissue-specific and sex-specific changes, including immune, metabolic, stress response and mitochondrial pathways.

Statins are effectively used to prevent and manage cardiovascular disease, but patient response to these drugs is highly variable. Here, the authors identify two new genes associated with the response of LDL cholesterol to statins and advance our understanding of the genetic basis of drug response.

Multi-omic single-cell and spatial analyses of lung cancer brain metastases from multiple cohorts identify high levels of chromosomal instability and a neural-like profile in brain metastases compared with primary tumors.

Many genetic variants have been associated with human traits, but the mechanism is often unknown. Here, the authors integrate local and distal genetic associations with multi-omics datasets to provide a roadmap to understand the underlying mechanisms of GWAS variants on complex traits.

Clinical multi-omics data are integrated and analyzed using a generative deep-learning model.

Multipartite entanglement is of both fundamental and practical interest, but is notoriously difficult to witness and characterise. Here, Zarkeshian et al. demonstrate multipartite entanglement in an atomic frequency comb storing a single photon in a Dicke state spread over a macroscopic ensemble.

A normative digital atlas of fetal brain maturation produced using 1,059 optimal quality, three-dimensional ultrasound brain volumes from 899 fetuses presents a unique spatiotemporal benchmark from a large cohort with normative postnatal growth and neurodevelopment at 2 years of age.

Distinct processing of objects and space has been an organizing principle for studying higher-level vision and medial temporal lobe memory. Here Connor and Knierim discuss instead how spatial information, on both local and global scales, is deeply integrated into the ventral-temporal object-processing pathway in vision and memory.

Patrick Ellinor and colleagues report meta-analyses of common and rare variant association studies for atrial fibrillation across multiple populations. They identify 12 new loci, some of which implicate genes in atrial electrical and mechanical function.

Multiple sclerosis is associated with a deficiency in generation of mature oligodendroctyes; an image-based screen for oligodendrocyte differentiation inducers identified the compound benztropine, which enhances remyelination acting through muscarinic receptors and decreases clinical severity in a multiple sclerosis model system.

Rich evidence of the potential co-benefits and trade-offs of natural climate solutions is available but remains poorly understood. Assessing the literature with machine learning methods, this study maps and analyses the growing evidence of trade-offs in natural climate solutions globally.

Low-noise amplification of feeble microwave signals is essential for superconducting quantum circuitry. Now, a gate-tunable Josephson parametric amplifier made from graphene shows 24 dB amplification paired with 10 MHz bandwidth and –130 dBm saturation power.

Hydropower will be an important source to meet the increasing energy needs in Africa, yet it is also faced with growing climate-induced risks. Regional interconnections among power pools and variable renewable energy could both help to reduce capacity loss and variability.

The levels of 1,251 metabolites are measured in 475 phenotyped individuals, and machine-learning algorithms reveal that diet and the microbiome are the determinants with the strongest predictive power for the levels of these metabolites.

This study finds germline loss-of-function mutations in HAVCR2, which encodes the immune modulator TIM-3, in individuals with subcutaneous panniculitis-like T cell lymphomas and hemophagocytic lymphohistiocytosis, a life-threatening inflammatory condition.