The peptidase DPP4 has a wide variety of target proteins, including the chemokine SDF-1 and the hormone GLP-1. Hal Broxmeyer and his coworkers now identify colony-stimulating factors as a new class of DPP4 substrates, including GM-CSF, G-CSF, IL-3 and erythropoietin. Treatment of mice with a clinically approved, orally available DPP4 inhibitor improved hematopoietic recovery after radiation or chemotherapeutic drug administration, pointing to potential clinical applications of these findings.
- Hal E Broxmeyer
- Jonathan Hoggatt
- Timothy B Campbell
