Nucleophiles are versatile reagents that can engage in a plethora of C–C and C–heteroatom bond-forming reactions. This Review examines their increasing role in transition metal-catalysed directed C–H functionalization, with a focus on synthetic approaches involving organometallic nucleophiles and X-based (X = N, O and S) coupling partners.
- Sergio Barranco
- Jiayu Zhang
- Mónica H. Pérez-Temprano
