Nature Search

Interferon subverts an AHR–JUN axis to promote CXCL13⁺ T cells in lupus

Insufficient AHR activation has been suggested in SLE, and augmenting AHR activation therapeutically may prevent CXCL13⁺ T_PH/T_FH differentiation and the subsequent recruitment of B cells and formation of lymphoid aggregates in inflamed tissues.

Calvin Law
Vanessa Sue Wacleche
Deepak A. Rao
Research10 Jul 2024
Nature

Volume: 631, P: 857-866
Nature of the Circulating Thyroid Hormone - Plasma Protein Complex

A. H. GORDON
J. GROSS
ROSALIND PITT-RIVERS
Research05 Jan 1952
Nature

Volume: 169, P: 19-20
A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia

Tiziana Borsello
Peter G H Clarke
Christophe Bonny
Research24 Aug 2003
Nature Medicine

Volume: 9, P: 1180-1186
SIRT2-mediated deacetylation of LCK governs the magnitude of T cell receptor signaling

Phosphorylation-dephosphorylation and ubiquitination tune TCR signaling to avoid self-reactivity. Kim and colleagues show that acetylation also modulates TCR signaling.

Imene Hamaidi
Pingyan Cheng
Sungjune Kim
ResearchOpen Access29 Jan 2026
Nature Immunology

Volume: 27, P: 213-224
Nature of the Pulsating Radio Sources

H. M. VAN HORN
Research23 Nov 1968
Nature

Volume: 220, P: 762-763
Seq-Scope-eXpanded: spatial omics beyond optical resolution

High spatial resolution is essential for resolving cellular and subcellular organization in tissues. Here, authors present Seq-Scope-X, which integrates tissue expansion with Seq-Scope to achieve an order-of-magnitude improvement in resolution of spatial transcriptomics and proteomics.

Angelo Anacleto
Weiqiu Cheng
Jun Hee Lee
ResearchOpen Access10 Feb 2026
Nature Communications

P: 1-20
c-Jun is essential for normal mouse development and hepatogenesis

Frank Hilberg
Adriano Aguzzi
Erwin F. Wagner
Research09 Sept 1993
Nature

Volume: 365, P: 179-181
Phosphoproteomics of aged insulin-resistant bone identifies P70S6K phosphorylation of AFF4 as a gene-specific transcriptional regulator

Insulin signaling plays a crucial role in coordinating skeletal development with whole‑body energy metabolism. Here, the authors use phosphoproteomics to show insulin-signaling rewiring in aged, insulin-resistant bone and identify defective phosphorylation of AFF4 as a key mechanism for regulating gene-specific transcriptional activation.

Mriga Dutt
Luoping Liao
Benjamin L. Parker
ResearchOpen Access31 Dec 2025
Nature Communications

Volume: 17, P: 1-23
From nicotine to SARS-CoV-2 antivirals with potent in vivo efficacy and a broad anti-coronavirus spectrum

Here the authors identify nicotine-derived inhibitors of the SARS-CoV−2 main protease that outperform Paxlovid in cells and mice, remain effective against resistant variants, and show broad activity against multiple human coronaviruses.

Kaustav Khatua
Sandeep Atla
Wenshe Ray Liu
ResearchOpen Access14 Feb 2026
Nature Communications

P: 1-13
Essential role of Jun family transcription factors in PU.1 knockdown–induced leukemic stem cells

Ulrich Steidl
Frank Rosenbauer
Daniel G Tenen
Research15 Oct 2006
Nature Genetics

Volume: 38, P: 1269-1277
Signalling inhibition by ponatinib disrupts productive alternative lengthening of telomeres (ALT)

The kinase inhibitor Ponatinib inhibits an ABL1-JUN signalling axis and alters telomere homeostasis, reduces telomere synthesis, and provokes telomere dysfunction in cancer cells which employ the alternative lengthening of telomeres mechanisms.

Frances Karla Kusuma
Aishvaryaa Prabhu
Maya Jeitany
ResearchOpen Access06 Apr 2023
Nature Communications

Volume: 14, P: 1-15
Atlas-guided discovery of transcription factors for T cell programming

A comprehensive atlas platform integrating transcriptional and epigenetic data enables more precise engineering of T cell states, accelerating the rational design of more effective cellular immunotherapies.

H. Kay Chung
Cong Liu
Wei Wang
ResearchOpen Access04 Feb 2026
Nature

P: 1-11
p73 supports cellular growth through c-Jun-dependent AP-1 transactivation

Faina Vikhanskaya
Wen Hong Toh
Kanaga Sabapathy
Research13 May 2007
Nature Cell Biology

Volume: 9, P: 698-706
Publisher Correction: Interferon subverts an AHR–JUN axis to promote CXCL13⁺ T cells in lupus

Calvin Law
Vanessa Sue Wacleche
Deepak A. Rao
Amendments and Corrections26 Jul 2024
Nature

Volume: 632, P: E6
Disease-linked regulatory DNA variants and homeostatic transcription factors in epidermis

Here the authors use a range of approaches to examine the interplay between genetic variants linked to risk for polygenic skin diseases and transcription factors (TFs) important for skin homeostasis. The findings implicate dysregulated binding of specific TF families in risk for diverse skin diseases.

Douglas F. Porter
Robin M. Meyers
Paul A. Khavari
ResearchOpen Access25 Sept 2025
Nature Communications

Volume: 16, P: 1-28
Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer’s pathology

Native state proteomics of PV interneurons revealed unique molecular features of high translational and metabolic activity, and enrichment of Alzheimer’s risk genes. Early amyloid pathology exerted unique effects on mitochondria, mTOR signaling and neurotransmission in PV neurons.

Prateek Kumar
Annie M. Goettemoeller
Srikant Rangaraju
ResearchOpen Access01 Apr 2024
Nature Communications

Volume: 15, P: 1-26
Regulatory grammar in human promoters uncovered by MPRA-based deep learning

PARM is a deep-learning model trained on data from massively parallel reporter assays to help predict promoter activity in different human cell types, design synthetic promoters and identify key features of regulatory promoter grammar.

Lucía Barbadilla-Martínez
Noud Klaassen
Bas van Steensel
ResearchOpen Access04 Feb 2026
Nature

P: 1-10
Lipid Nanoparticle Database towards structure-function modeling and data-driven design for nucleic acid delivery

This study introduces the Lipid Nanoparticle Database (LNPDB) and web tool that consolidates lipid nanoparticle structure-function data. LNPDB facilitates molecular dynamics and deep learning approaches to advance data-driven design for nucleic acid delivery.

Evan Collins
Jungyong Ji
Wonpil Im
ResearchOpen Access28 Jan 2026
Nature Communications

P: 1-14
Natural Regulation of Numbers in Primitive Human Populations

M. H. SKOLNICK
C. CANNINGS
Research29 Sept 1972
Nature

Volume: 239, P: 287-288
TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression

Insulin resistance is associated with development of type 2 diabetes. Here the authors show that TAZ interacts with c-Jun and Tead4, inducing expression of the insulin receptor substrate 1 (IRS1) leading to increased glucose uptake in muscle, and that its activity is counteracted by statin administration.

Jun-Ha Hwang
A Rum Kim
Jeong-Ho Hong
ResearchOpen Access24 Jan 2019
Nature Communications

Volume: 10, P: 1-11
Genetic modifiers of APOE-ε4-associated cognitive decline

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

Alex G. Contreras
Skylar Walters
Timothy J. Hohman
ResearchOpen Access20 Feb 2026
Nature Communications

P: 1-17
Harnessing glucocorticoid receptor antagonism to enhance the efficacy of cardiac regenerative growth factors and cytokines

Da Pra, Boriati and colleagues show that physiological glucocorticoids suppress growth-factor-induced cardiomyocyte regeneration by inhibiting ERK signaling and propose glucocorticoid receptor antagonism as a strategy to enhance their protective and regenerative effects.

Silvia Da Pra
Stefano Boriati
Gabriele D’Uva
Research06 Feb 2026
Nature Cardiovascular Research

P: 1-20
Nature of Reticulin

K. LITTLE
H. KRAMER
Research20 Sept 1952
Nature

Volume: 170, P: 499-500
Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages

Transcription factors of the AP-1 family can play diverse roles despite recognizing the same DNA sequence. Here the authors investigate the DNA binding activities of AP-1 members in mouse macrophages and apply a machine learning approach to identify motifs predicted to drive factor-specific binding profiles.

Gregory J. Fonseca
Jenhan Tao
Christopher K. Glass
ResearchOpen Access24 Jan 2019
Nature Communications

Volume: 10, P: 1-16
Genetic dissection of axon regeneration via in vivo electroporation of adult mouse sensory neurons

Dorsal root ganglion neurons can regenerate after injury, but the mechanisms underlying axon regrowth are unclear. To address this, an electroporation transfection method is developed that can alter the gene expression of dorsal root ganglion cells in a living adult mouse, providing a tool to study axon regeneration.

Saijilafu
Eun-Mi Hur
Feng-Quan Zhou
Research22 Nov 2011
Nature Communications

Volume: 2, P: 1-10
Clonal CD8⁺ T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases

Elyaman and colleagues performed comparative single-cell transcriptomic and TCR repertoire analyses on T cells obtained from human cadaver brain and leptomeningeal tissues from individuals diagnosed with neurodegenerative disease.

Ryan Hobson
Samuel H. S. Levy
Wassim Elyaman
ResearchOpen Access27 Jan 2026
Nature Immunology

Volume: 27, P: 323-335
Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy

Perineural invasion and cancer-induced nerve injury of tumour-associated nerves are associated with poor response to anti-PD-1 therapy, which can be reversed by combining anti-PD-1 therapy with anti-inflammatory interventions.

Erez N. Baruch
Frederico O. Gleber-Netto
Moran Amit
ResearchOpen Access20 Aug 2025
Nature

Volume: 646, P: 462-473
Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors

In fibrotic biliary disease, portal fibroblasts promote both biliary scarring and bile duct regeneration. Here, the authors report that the non-canonical Wnt-PCP signalling promotes bile duct scarring in mice, and inhibition of Wnt-ligands reduces the scarring without impairing regeneration.

D. H. Wilson
E. J. Jarman
L. Boulter
ResearchOpen Access23 Jan 2020
Nature Communications

Volume: 11, P: 1-13
Calcineurin-mediated dephosphorylation of c-Jun Ser-243 is required for c-Jun protein stability and cell transformation

C-C Huang
J-M Wang
W-C Chang
Research22 Oct 2007
Oncogene

Volume: 27, P: 2422-2429
Generation of functionally distinct T-cell populations by altering the viscoelasticity of their extracellular matrix

Functionally distinct T-cell populations can be generated from T cells that received the same stimulation by altering the viscoelasticity of their surrounding extracellular matrix.

Kwasi Adu-Berchie
Yutong Liu
David J. Mooney
Research26 Jun 2023
Nature Biomedical Engineering

Volume: 7, P: 1374-1391
Diurnal Variation in Organismic Response to Very Weak Gamma Radiation

FRANK A. BROWN JUN.
YOUNG H. PARK
JOSEPH R. ZENO
Research20 Aug 1966
Nature

Volume: 211, P: 830-833
Dominant negative c-Jun gene transfer inhibits vascular smooth muscle cell proliferation and neointimal hyperplasia in rats

H Yasumoto
S Kim
H Iwao
Research17 Dec 2001
Gene Therapy

Volume: 8, P: 1682-1689
Regorafenib is effective against neuroblastoma in vitro and in vivo and inhibits the RAS/MAPK, PI3K/Akt/mTOR and Fos/Jun pathways

Divya Subramonian
Nikki Phanhthilath
Peter E. Zage
ResearchOpen Access27 May 2020
British Journal of Cancer

Volume: 123, P: 568-579
Target protein deglycosylation in living cells by a nanobody-fused split O-GlcNAcase

Fusion of a split form of the protein O-GlcNAcase with nanobodies enables the targeted removal of O-GlcNAc protein modifications, providing a tool for probing the functional roles of specific O-GlcNAc modifications in a cellular context.

Yun Ge
Daniel H. Ramirez
Christina M. Woo
Research08 Mar 2021
Nature Chemical Biology

Volume: 17, P: 593-600
Ootheca Wolleyana, an illustrated Ca?gue of the Collection of Birds' Eggs formed by the late John Wolley, jun

W. H. H.
Books & Arts11 Jul 1907
Nature

Volume: 76, P: 241-244
In vivo CRISPR inactivation of Fos promotes prostate cancer progression by altering the associated AP-1 subunit Jun

Maria Riedel
Martin F. Berthelsen
Martin K. Thomsen
Research05 Mar 2021
Oncogene

Volume: 40, P: 2437-2447
Engineered mucus-tethering bispecific nanobodies enhance mucosal immunity against respiratory pathogens

Engineered mucus-tethering bispecific nanobodies neutralize and entrap viruses to enhance mucosal immunity, preventing influenza infection and limiting SARS-CoV-2 transmission.

Liming Zhao
Kyle L. O’Donnell
Charles K. F. Chan
Research21 Jan 2026
Nature Nanotechnology

P: 1-11
Altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in MED12 mutant uterine leiomyomas

Somatic mutations in MED12 have been implicated as the causal genetic lesion in the majority of uterine leiomyomas. Here, the authors profile the chromatin landscape of matched normal and leiomyoma tissues and find that changes in enhancer acetylation, enhancer-promoter interaction strength, differential enhancer usage and transcription factor AP-1 occupancy are significant drivers of transcriptional dysregulation in MED12 mutant leiomyomas.

Mthabisi B. Moyo
J. Brandon Parker
Debabrata Chakravarti
ResearchOpen Access24 Feb 2020
Nature Communications

Volume: 11, P: 1-16
Charting brain morphology in international healthy and neurological populations

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Zhizheng Zhuo
Li Chai
Yaou Liu
Research29 Dec 2025
Nature Neuroscience

Volume: 29, P: 420-434
Fine particulate matter (PM2.5) inhibits ciliogenesis by increasing SPRR3 expression via c-Jun activation in RPE cells and skin keratinocytes

Ji-Eun Bae
Hyunjung Choi
Dong-Hyung Cho
ResearchOpen Access08 Mar 2019
Scientific Reports

Volume: 9, P: 1-9
Small alkali cations direct CO electroreduction to hydrocarbons rather than oxygenates

Electrochemical CO reduction to multi-carbon products offers a carbon-negative approach to produce chemicals, but the intricate reaction pathways lead to a broad spectrum of products. Now it has been shown that alkali cations alter the mechanistic pathways that govern the reaction selectivity involved in the formation of hydrocarbons versus oxygenates.

Weiyan Ni
Yongxiang Liang
Edward H. Sargent
Research29 Jan 2026
Nature Chemistry

P: 1-8
Cytostatic Antibody and SV40 Tumour Immunity in Hamsters

KATHLEEN R. AMBROSE
N. G. ANDERSON
J. H. COGGIN jun.
Research01 Oct 1971
Nature

Volume: 233, P: 321-324
FGF18–FGFR2 signaling triggers the activation of c-Jun–YAP1 axis to promote carcinogenesis in a subgroup of gastric cancer patients and indicates translational potential

Jinglin Zhang
Chi Chun Wong
Wei Kang
ResearchOpen Access15 Sept 2020
Oncogene

Volume: 39, P: 6647-6663
Seasonal Variations in Sign and Strength of Gamma-Taxis in Planarians

F. A. BROWN jun.
Y. H. PARK
Research02 May 1964
Nature

Volume: 202, P: 469-471
Altered regulation of c-jun and its involvement in anchorage-independent growth of human lung cancers

K Maeno
A Masuda
T Takahashi
Research12 Sept 2005
Oncogene

Volume: 25, P: 271-277
Dominant-negative mutant of c-Jun gene transfer: a novel therapeutic strategy for colorectal cancer

R Suto
K Tominaga
T Arakawa
Research08 Jan 2004
Gene Therapy

Volume: 11, P: 187-193
Orbital Seebeck effect induced by chiral phonons

Generation of orbital currents in a non-magnetic material can be useful to build efficient orbitronic devices. Now, the interplay of chiral phonons and electrons is shown to produce orbital currents in α-quartz.

Yoji Nabei
Cong Yang
Dali Sun
Research21 Jan 2026
Nature Physics

Volume: 22, P: 245-251
Restriction of innate Tγδ17 cell plasticity by an AP-1 regulatory axis

Ciofani and colleagues examine the plasticity of Tγδ17 cells in the gut, where they identify a role for the AP-1 transcription factors JUNB and FOSL2 in restricting type 1 plasticity.

Morgan E. Parker
Naren U. Mehta
Maria Ciofani
Research27 Jun 2025
Nature Immunology

Volume: 26, P: 1299-1314
Is Glycine a Neurotransmitter ?: Inhibition of Motoneurones by Iontophoresis of Glycine

R. WERMAN
R. A. DAVIDOFF
M. H. APRISON
Research13 May 1967
Nature

Volume: 214, P: 681-683
BCR–ABL promotes neutrophil differentiation in the chronic phase of chronic myeloid leukemia by downregulating c-Jun expression

S Kobayashi
F Kimura
K Motoyoshi
Research09 Apr 2009
Leukemia

Volume: 23, P: 1622-1627

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