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Showing 1–4 of 4 results
Advanced filters: Author: H Tawakol Clear advanced filters

  • PET imaging using 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) has been widely used for the detection of plaque inflammation. Here, however, Nobuhiro Tahara and colleagues explore the possibility of using 18F-labeled mannose (2-deoxy-2-[18F]fluoro-d-mannose, [18F]FDM), a structural analog to FDG, as an alternative and potentially more specific PET tracer than FDG for assessing the risk of acute vascular events in patients. The approach targets the mannose receptor–bearing macrophages that are abundant in high-risk atherosclerotic plaques, with feasibility demonstrated in a rabbit model of atherosclerosis.

    • Nobuhiro Tahara
    • Jogeshwar Mukherjee
    • Jagat Narula
    Research
    Nature Medicine
    Volume: 20, P: 215-219

  • Combination antiretroviral therapy (cART) has substantially prolonged the lives of patients with HIV infection, but these individuals have an increased risk of coronary heart disease and myocardial infarction compared with uninfected individuals. In this Review, Reiss and colleagues discuss the control of both traditional and immune risk factors, and the appropriate selection of cART regimens, to reduce the risk of cardiovascular complications in patients with HIV.

    • Markella V. Zanni
    • Judith Schouten
    • Peter Reiss
    Reviews
    Nature Reviews Cardiology
    Volume: 11, P: 728-741