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Showing 1–8 of 8 results
Advanced filters: Author: H Wiendl Clear advanced filters

  • Regulatory T (TREG) cells are emerging as key players in the pathogenetic scenario of CNS autoimmune inflammation. In this article, Zozulya and Wiendl discuss how TREG-cell dysfunction might influence the disease course in multiple sclerosis and experimental autoimmune encephalomyelitis, highlighting the importance of interactions between TREGcells and dendritic cells. The authors also assess the potential for therapeutic use of these cell types in patients with multiple sclerosis.

    • Alla L Zozulya
    • Heinz Wiendl
    Reviews
    Nature Clinical Practice Neurology
    Volume: 4, P: 384-398

  • Baló's concentric sclerosis (BCS) is a demyelinating disorder characterized by white matter lesions consisting of rings of demyelination alternating with rings of relatively intact myelin. In this Review, Mowryet al.discuss how advanced neuroimaging techniques have contributed to our understanding of the pathogenesis of BCS, as well as enabling clinicians to distinguish BCS from other demyelinating disorders such as multiple sclerosis. The authors explore these themes further in a Case Study in this issue.

    • Ellen M Mowry
    • John H Woo
    • Beau M Ances
    Reviews
    Nature Clinical Practice Neurology
    Volume: 3, P: 341-348

  • Approximately half of the people currently with multiple sclerosis (MS) are ≥50 years of age, yet guidelines for management of MS in older age are lacking. This Consensus statement presents the outcomes of an International Advisory Committee on Clinical Trials (IACCT) in MS workshop on ageing and MS, including recommendations for advancing research, care and awareness.

    • Anneke van der Walt
    • Eva M. M. Strijbis
    • Yinan Zhang
    Reviews
    Nature Reviews Neurology
    Volume: 21, P: 432-448