Search

The controlled manipulation of the topological phases of electronic materials is a central goal of modern condensed matter research. Here, the authors demonstrate controllable switching between two distinct topological phases in a layered ferromagnet via thermal cycling.

Measurements of a superconducting infinite-layer nickelate show that its upper critical field is largely isotropic despite its quasi-two-dimensional structure. This indicates that, unusually for layered oxides, the superconductivity is Pauli-limited.

Removal of integrated HIV DNA remains a roadblock for HIV cure. Here, Mancuso et al. show that intravenous administration of an adeno-associated virus-based CRISPR/Cas9 gene editing construct to SIV-infected macaques results in excision of integrated proviral DNA from infected blood cells and tissues known to be viral reservoirs.

Lipopeptides secreted by Bacillus bacteria block quorum sensing by Staphylococcus aureus and thereby inhibit the growth of this opportunistic pathogen in the gut, suggesting why people in rural Thailand who are colonized by Bacillus are not also colonized by S. aureus.

White matter hyperintensities (WMH) are a common brain-imaging feature of cerebral small vessel disease. Here, the authors carry out a GWAS and followup analyses for WMH-volume, implicating several variants with potential for risk stratification and drug targeting.

Nickelate superconductivity has so far been limited to thin films, raising questions about the role of the polar substrate–film interface. Here the authors utilize advanced characterization techniques to reveal the interfacial atomic structure and its relevance for superconductivity.

A detailed neutron scattering and muon spin relaxation study uncovers a continuum of magnetic excitations down to 35 mK in the pyrochlore lattice compound Ce₂Zr₂O₇ with minimum chemical disorder, consistent with quantum spin liquid behaviour.

Meta-analysis of 36,760 cases and 375,188 controls identifies 54 loci associated with susceptibility to cutaneous melanoma. Further analysis combining nevus count and hair color GWAS results provide insights into the genetic architecture of melanoma.

The average body size of salmon has declined rapidly over recent decades. Here the authors quantify changes in body size distributions for Pacific salmon in Alaska and examine the causes and consequences of size declines for ecosystems, food security, and commercial fisheries.

Most quantum technologies rely upon quantum wires to ensure the faithful transfer of quantum states between remote locations—a process that is especially vulnerable to decoherence. Yao et al.propose a means to harness topological protection to design a quantum wire that is intrinsically robust against decoherence.

We propose and experimentally demonstrate a new paradigm for parameter-efficient and robust photonic deep learning based on a Neural Cellular Automata architecture.

A catalogue of predicted loss-of-function variants in 125,748 whole-exome and 15,708 whole-genome sequencing datasets from the Genome Aggregation Database (gnomAD) reveals the spectrum of mutational constraints that affect these human protein-coding genes.

The millimetre image of the Centaurus A nucleus by the Event Horizon Telescope reveals a highly collimated, asymmetrically edge-brightened jet. The source’s event horizon shadow should be visible at terahertz frequencies, consistent with the universal scale invariance of black holes.

Dysregulated phosphorylation is well-known in cancers, but it has largely been studied in isolation from mutations. Here the authors introduce HotPho, a tool that can discover spatial interactions between phosphosites and mutations, which are associated with activating mutation and genetic dependencies in cancer.

Aegilops sharonensis is a wild diploid relative of wheat. Here, the authors assemble the genome of Ae. sharonensis and use the assembly as an aid to clone the Ae. sharonensis-derived stem rust resistance gene Sr62 in the allohexaploid genome of wheat.

Molecular collisions can lead to the absorption of incident light even for transitions that are spectroscopically forbidden for the isolated molecules. Now the electronic–vibrational transitions of O₂ have been theoretically studied and, contrary to textbook knowledge, it is shown that the absorption mechanism and the spectral line shape depend on the collision partner, oxygen or nitrogen.

Coherent control and giant modulation of optical nonlinearity in a van der Waals layered magnetic insulator is demonstrated using Floquet engineering.

Irreproducibility of biological findings is a major challenge for drug development. Here the authors examine the lifespans of 22 worm strains in three different laboratories and the effects of ten known chemicals to assess reproducibility in the face of variations in genetic background, chemical treatment and lab environment.

Photoinduced electron transfer through, and between, pyrrole moieties is an important process both in the natural world and emerging technologies. Here, the authors use both experiment and theoretical calculation to investigate a previously undiscovered relaxation pathway arising in pyrrole dimers.

We experimentally demonstrate a special-purpose photonic computer as a novel hardware platform for simulating complex phenomena using cellular automata.

Analysis of transits of an ultra-hot giant exoplanet reports the precise abundance constraints of 14 major refractory elements, showing distinct deviations from proto-solar, along with a sharp transition temperature at which those elements are depleted.

A retrievable, porous and anti-fibrotic macrodevice for the encapsulation of cells provides long-term protection to human cells expressing therapeutic proteins after device implantation in the intraperitoneal space of immunocompetent mice.

Here the authors studied pulmonary arterial endothelial cells (PAEC) under laminar shear stress and show that this physiologic condition markedly changes chromatin accessibility at regulatory regions, when compared to cells grown in a static state. They find that KLF4 organizes chromatin by interacting with the SWI/SNF nucleosome remodeling complex to regulate vasculo-protective gene expression.

Carotenoid biosynthesis requires isomerization of the central double bond. Informatic, spectroscopic and functional characterization of Z-ISO, a protein involved in the process, demonstrates that it is a standalone enzyme with unusual heme-dependent chemistry.

Mechanical and electrical activity in the heart is propagated through unique cardiomyocyte membrane structures, the intercalated discs (ID). Sharma et al.identify a novel ID protein, Tmem65, that controls Ca2+ signalling and electrical coupling by interacting with and functionally regulating the gap junction protein Cx43.

A new method to quantify three masting components from individual tree-years has revealed that globally, masting is uncommon in tree species that depend on mutualist dispersers, with its distribution further mediated by climate and nutrient availability.

The coexistence of chiral edge states and chiral spin textures in magnetic topological insulator sandwiches provides a platform for proof-of-concept dissipationless spin-textured spintronic applications.

The heterogeneity of breast cancer has a major role in drug response and resistance. In this study, the authors use patient-derived tumour xenografts as a platform for drug testing and correlation with single-cell proteomic phenotypes characterized by mass cytometry.

Methane emissions from aquatic systems contribute approximately half of global methane emissions, according to meta-analysis of natural, impacted and human-made aquatic ecosystems and indicating potential mitigation strategies to reduce emissions.

This Perspective introduces energy decomposition analysis as a means of providing a quantum chemically derived bonding model that we can use to rationalize molecular geometries and bonding. The model serves as a bridge between the simple Lewis electron-pair bond and the complicated quantum theoretical nature of the chemical bond.

Subarcsecond localization of the repeating fast radio burst FRB 121102 shows that its source is co-located with a faint galaxy with a low-luminosity active galactic nucleus, or a previously unknown type of extragalactic source.

The accelerations of a pulsar and a white dwarf in a three-star system differ by at most a few parts per million, providing a much improved constraint on the universality of free fall.