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Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse

Identifying the molecular mechanisms of response to systemic therapy in prostate cancer remains crucial. Here, the authors apply single cell-ATAC and RNAseq to models of early treatment response and resistance to enzalutamide and identify chromatin and gene expression patterns that can predict treatment response.

S. Taavitsainen
N. Engedal
A. Urbanucci
ResearchOpen Access06 Sept 2021
Nature Communications

Volume: 12, P: 1-16
Statins and prostate cancer prevention: where we are now, and future directions

Many experimental studies have reported that statins, cholesterol-lowering drugs, inhibit the growth of prostate cancer cells. In this Review, Murtola and colleagues look at the current evidence on the use of statins in the prevention of prostate cancer.

Teemu J Murtola
Tapio Visakorpi
Teuvo LJ Tammela
Reviews10 Jun 2008
Nature Clinical Practice Urology

Volume: 5, P: 376-387
Altered levels of Smad2 and Smad4 are associated with human prostate carcinogenesis

M C Perttu
P M Martikainen
H Syvälä
Research21 Mar 2006
Prostate Cancer and Prostatic Diseases

Volume: 9, P: 185-189

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