Nature Search

Elevated uric acid induces erectile dysfunction in rats by interacting with MLCK and inhibiting its ubiquitin-mediated degradation

Elevated uric acid induces early erectile dysfunction by interacting with MLCK and by inhibiting its ubiquitin-mediated degradation. MLCK inhibitor ML-7 and uric acid-lowering therapy improve erectile function induced by hyperuricemia.

Gang Shen
Zhenzhen Fang
Ti Zhou
ResearchOpen Access09 Aug 2025
Communications Biology

Volume: 8, P: 1-15
Machine learning for synchronous bone metastasis risk prediction in high grade lung neuroendocrine carcinoma

Bo Lan
Zongyun He
Jin Yang
ResearchOpen Access09 Jul 2025
Scientific Reports

Volume: 15, P: 1-11
An adaptive AI-based virtual reality sports system for adolescents with excess body weight: a randomized controlled trial

A reinforcement learning-based virtual reality system, implementing a series of sport sessions with coaching, was as effective as standard physical activity in reducing fat mass in adolescents, with positive effects on cognition.

Jihong Wang
Yiming Qin
Huating Li
ResearchOpen Access23 Jun 2025
Nature Medicine

Volume: 31, P: 2255-2268
A conserved Phytophthora apoplastic trypsin-like serine protease targets the receptor-like kinase BAK1 to dampen plant immunity

Phytophthora secretes a conserved trypsin-like serine protease, PsTry1, that suppresses apoplastic immunity by cleaving the extracellular domain of the co-receptor BAK1, revealing a novel mechanism by which pathogens overcome apoplastic immune defences.

Sicong Zhang
Liyuan Wang
Yan Wang
Research01 Jul 2025
Nature Plants

Volume: 11, P: 1401-1415
Correction: Corrigendum: Diabetes Onset at 31–45 Years of Age is Associated with an Increased Risk of Diabetic Retinopathy in Type 2 Diabetes

Wenjun Zou
Lisha Ni
Zhi Zheng
Amendments and CorrectionsOpen Access26 May 2017
Scientific Reports

Volume: 7, P: 1
A highly selective and recyclable NO-responsive nanochannel based on a spiroring opening−closing reaction strategy

Constructing artificial ion channels to mimic biological process is highly demanded but currently artificial ion channels lack robustness. Here the authors report a robust NO-regulated artificial nanochannel based on a spiro ring opening−closing reaction strategy.

Yao Sun
Sen Chen
Haibing Li
ResearchOpen Access21 Mar 2019
Nature Communications

Volume: 10, P: 1-8
Efficient syngas conversion via catalytic shunt

Catalytic syngas conversion is an essential part of sustainable chemical production but is hindered by the trade-off between conversion activity and product selectivity. Here the authors address this challenge by developing a catalytic shunt strategy.

Guo Tian
Zhengwen Li
Fei Wei
Research01 May 2025
Nature Sustainability

Volume: 8, P: 508-519
Suppressing wide-angle light loss and non-radiative recombination for efficient perovskite solar cells

The incorporation of fluorine-doped tin oxide nanoplatelets on the substrate of perovskite solar cells contributes to uniform light harvesting across different incidence angles of sunlight. The best devices show a power conversion efficiency of 26.4% (certified 25.9%), 95% of which is maintained after 1,200 hours of operation.

Yansong Ge
Likai Zheng
Guojia Fang
Research09 Jan 2025
Nature Photonics

Volume: 19, P: 170-177
Real-space imaging for discovering a rotated node structure in metal-organic framework

Resolving the structures of MOFs is significant for understanding their structure-property relation. Here, authors apply a low-dose imaging technique to resolve the atomic structures of building units in MOF MIL-125. A low-symmetry structure of MIL-125 is discovered by directly imaging the rotated Ti-O nodes, different from the unrotated one predicted in previous works.

Jiale Feng
Zhipeng Feng
Boyuan Shen
ResearchOpen Access13 Aug 2024
Nature Communications

Volume: 15, P: 1-8
An alkaloid initiates phosphodiesterase 3A–schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity

PDE3A modulators for cancer therapy cause serious side effects as they inhibit PDE3A phosphodiesterase activity, which is essential for the maturation of oocytes and the formation of platelets. Here, the authors identify a compound, nauclefine, that does not inhibit PDE3A activity but induces apoptosis by enabling a complex formation between PDE3A and SLFN12.

Youwei Ai
Haibing He
Xiangbing Qi
ResearchOpen Access26 Jun 2020
Nature Communications

Volume: 11, P: 1-10
Urate in fingernail represents the deposition of urate burden in gout patients

Haibing Chen
Lili Zhao
Jun Zhe Min
ResearchOpen Access23 Sept 2020
Scientific Reports

Volume: 10, P: 1-8
Middle ear innovation in Early Cretaceous eutherian mammals

The evolution of the middle ear in early therians is unclear. Here, the authors report a reconstructed, detached middle ear in a eutherian mammal from the Early Cretaceous Jehol Biota, suggesting independent decoupling of hearing and chewing apparatuses.

Haibing Wang
Yuanqing Wang
ResearchOpen Access26 Oct 2023
Nature Communications

Volume: 14, P: 1-11
Stable and low-photovoltage-loss perovskite solar cells by multifunctional passivation

The use of a dimensionally graded 2D perovskite interface and passivation results in perovskite solar cells with very low photovoltage loss.

Guang Yang
Zhiwei Ren
Gang Li
Research05 Jul 2021
Nature Photonics

Volume: 15, P: 681-689
LncRNA CCAT2, involving miR-34a/TGF-β1/Smad4 signaling, regulate hepatic stellate cells proliferation

Haibing Gao
Xiangmei Wang
Dongliang Li
ResearchOpen Access08 Dec 2022
Scientific Reports

Volume: 12, P: 1-14
Diabetes Onset at 31–45 Years of Age is Associated with an Increased Risk of Diabetic Retinopathy in Type 2 Diabetes

Wenjun Zou
Lisha Ni
Zhi Zheng
ResearchOpen Access29 Nov 2016
Scientific Reports

Volume: 6, P: 1-5
Discovery of a ZIP7 inhibitor from a Notch pathway screen

A cell-based phenotypic screen identifying inhibitors of Notch signaling led to the discovery of NVS-ZP7-4, which blocks the activity of the zinc transporter SLC39a7 (ZIP7) and induces cell death through an ER stress mechanism.

Erin Nolin
Sara Gans
Christy J. Fryer
Research14 Jan 2019
Nature Chemical Biology

Volume: 15, P: 179-188
APOE4 impairs macrophage lipophagy and promotes demyelination of spiral ganglion neurons in mouse cochleae

Junru Chen
Haibing Chen
Jun Yao
ResearchOpen Access21 Apr 2025
Cell Death Discovery

Volume: 11, P: 1-10
The chloride/phosphate ratio combined with alkaline phosphatase as a valuable predictive marker for primary hyperparathyroidism in Chinese individuals

Qianqian Wang
Xu Li
Weiping Jia
ResearchOpen Access07 Jul 2017
Scientific Reports

Volume: 7, P: 1-7
Decreased levels of Fibroblast Growth Factor 21 are correlated with improved hypoglycemia in patients with insulinoma

Xu Li
Haoyong Yu
Weiping Jia
ResearchOpen Access22 Feb 2017
Scientific Reports

Volume: 7, P: 1-7
Hyperuricemia and overexcretion of uric acid increase the risk of simple renal cysts in type 2 diabetes

Ying Han
Mingliang Zhang
Weiping Jia
ResearchOpen Access19 Jun 2017
Scientific Reports

Volume: 7, P: 1-8
Dislocation response of ECC-RC composite supporting structures of tunnels passing through active fault

Shunguo Wang
Zude Ding
Juan Huang
ResearchOpen Access02 Jul 2024
Scientific Reports

Volume: 14, P: 1-22
Potential PeVatron supernova remnant G106.3+2.7 seen in the highest-energy gamma rays

Gamma-ray emission up to and above 100 TeV is detected from the supernova remnant G106.3+2.7. The emission above 10 TeV is associated with a molecular cloud rather than the pulsar PSR J2229+6114, favouring a hadronic origin via the π⁰ decay caused by accelerated relativistic protons.

M. Amenomori
Y. W. Bao
X. X. Zhou
Research01 Mar 2021
Nature Astronomy

Volume: 5, P: 460-464
Explainable machine learning model for predicting spontaneous bacterial peritonitis in cirrhotic patients with ascites

Yingying Hu
Ruijia Chen
Yongyi Zeng
ResearchOpen Access04 Nov 2021
Scientific Reports

Volume: 11, P: 1-11
MED15 is upregulated by HIF-2α and promotes proliferation and metastasis in clear cell renal cell carcinoma via activation of SREBP-dependent fatty acid synthesis

Xiaoliang Hua
Shengdong Ge
Chaozhao Liang
ResearchOpen Access22 Apr 2024
Cell Death Discovery

Volume: 10, P: 1-16
An effective way to control the radical reaction and its mechanism in EPDM under γ-ray irradiation

Yiyang Zhou
Qiuyue Meng
Yunsheng Ding
ResearchOpen Access11 Mar 2023
npj Materials Degradation

Volume: 7, P: 1-12
Correction to: Gene expression profiling in peripheral blood lymphocytes for major depression: preliminary cues from Chinese discordant sib-pair study

Chan Wu
Danfeng Wang
Hui Xiang
Amendments and CorrectionsOpen Access29 Nov 2021
Translational Psychiatry

Volume: 11, P: 1
LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma

KeShan Wang
TianBo Xu
XiaoPing Zhang
ResearchOpen Access15 Feb 2019
Cell Death & Disease

Volume: 10, P: 1-14
Nonalcoholic Fatty Liver Disease is Associated with Increased Carotid Intima-Media Thickness in Type 1 Diabetic Patients

Lei Zhang
Kaifeng Guo
Weiping Jia
ResearchOpen Access26 May 2016
Scientific Reports

Volume: 6, P: 1-8
Gene expression profiling in peripheral blood lymphocytes for major depression: preliminary cues from Chinese discordant sib-pair study

Chan Wu
Danfeng Wang
Hui Xiang
ResearchOpen Access19 Oct 2021
Translational Psychiatry

Volume: 11, P: 1-9
Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity

Xiujin Shen
Haibing Wang
Jianghua Chen
ResearchOpen Access15 Feb 2021
Cell Death & Disease

Volume: 12, P: 1-16
RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages

Liang Tao
Yuguo Yi
Dan Weng
Research18 Nov 2020
Cell Death & Differentiation

Volume: 28, P: 1418-1433
ETS2 promotes epithelial-to-mesenchymal transition in renal fibrosis by targeting JUNB transcription

High expression of the transcription factor ETS2 plays important role in a mouse model of renal fibrosis and in TGF-β1-treated human tubular epithelial cells (HK2). ETS2 promotes TGF-β1-induces epithelial-to-mesenchymal transition (EMT) phenotypic inversion and the expression of EMT markers in HK2 cells by enhancing transcription of JUNB. These findings suggest that ETS2 could be a novel target for the prevention the progression of renal fibrosis.

Fang Yao
Xiaojing Wang
Xiaochun Bai
Research22 Oct 2019
Laboratory Investigation

Volume: 100, P: 438-453
Calcineurin inhibitors cyclosporin A and tacrolimus protect against podocyte injury induced by puromycin aminonucleoside in rodent models

Xiujin Shen
Hong Jiang
Jianghua Chen
ResearchOpen Access01 Sept 2016
Scientific Reports

Volume: 6, P: 1-16
Dihydroartemisinin selectively inhibits PDGFRα-positive ovarian cancer growth and metastasis through inducing degradation of PDGFRα protein

Xiaoguang Li
Qian Ba
Hui Wang
ResearchOpen Access21 Nov 2017
Cell Discovery

Volume: 3, P: 1-13
Evolution and Function of Dinosaur Teeth at Ultramicrostructural Level Revealed Using Synchrotron Transmission X-ray Microscopy

Chun-Chieh Wang
Yen-Fang Song
Robert R. Reisz
ResearchOpen Access29 Oct 2015
Scientific Reports

Volume: 5, P: 1-11
Apoptotic cell death in disease—Current understanding of the NCCD 2023

Ilio Vitale
Federico Pietrocola
Lorenzo Galluzzi
Reviews26 Apr 2023
Cell Death & Differentiation

Volume: 30, P: 1097-1154

Search

Elevated uric acid induces erectile dysfunction in rats by interacting with MLCK and inhibiting its ubiquitin-mediated degradation

Machine learning for synchronous bone metastasis risk prediction in high grade lung neuroendocrine carcinoma

An adaptive AI-based virtual reality sports system for adolescents with excess body weight: a randomized controlled trial

A conserved Phytophthora apoplastic trypsin-like serine protease targets the receptor-like kinase BAK1 to dampen plant immunity

Correction: Corrigendum: Diabetes Onset at 31–45 Years of Age is Associated with an Increased Risk of Diabetic Retinopathy in Type 2 Diabetes

A highly selective and recyclable NO-responsive nanochannel based on a spiroring opening−closing reaction strategy

Efficient syngas conversion via catalytic shunt

Suppressing wide-angle light loss and non-radiative recombination for efficient perovskite solar cells

Real-space imaging for discovering a rotated node structure in metal-organic framework

An alkaloid initiates phosphodiesterase 3A–schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity

Urate in fingernail represents the deposition of urate burden in gout patients

Middle ear innovation in Early Cretaceous eutherian mammals

Stable and low-photovoltage-loss perovskite solar cells by multifunctional passivation

LncRNA CCAT2, involving miR-34a/TGF-β1/Smad4 signaling, regulate hepatic stellate cells proliferation

Diabetes Onset at 31–45 Years of Age is Associated with an Increased Risk of Diabetic Retinopathy in Type 2 Diabetes

Discovery of a ZIP7 inhibitor from a Notch pathway screen

APOE4 impairs macrophage lipophagy and promotes demyelination of spiral ganglion neurons in mouse cochleae

The chloride/phosphate ratio combined with alkaline phosphatase as a valuable predictive marker for primary hyperparathyroidism in Chinese individuals

Decreased levels of Fibroblast Growth Factor 21 are correlated with improved hypoglycemia in patients with insulinoma

Hyperuricemia and overexcretion of uric acid increase the risk of simple renal cysts in type 2 diabetes

Dislocation response of ECC-RC composite supporting structures of tunnels passing through active fault

Potential PeVatron supernova remnant G106.3+2.7 seen in the highest-energy gamma rays

Explainable machine learning model for predicting spontaneous bacterial peritonitis in cirrhotic patients with ascites

MED15 is upregulated by HIF-2α and promotes proliferation and metastasis in clear cell renal cell carcinoma via activation of SREBP-dependent fatty acid synthesis

An effective way to control the radical reaction and its mechanism in EPDM under γ-ray irradiation

Correction to: Gene expression profiling in peripheral blood lymphocytes for major depression: preliminary cues from Chinese discordant sib-pair study

LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma

Nonalcoholic Fatty Liver Disease is Associated with Increased Carotid Intima-Media Thickness in Type 1 Diabetic Patients

Gene expression profiling in peripheral blood lymphocytes for major depression: preliminary cues from Chinese discordant sib-pair study

Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity

RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages

ETS2 promotes epithelial-to-mesenchymal transition in renal fibrosis by targeting JUNB transcription

Calcineurin inhibitors cyclosporin A and tacrolimus protect against podocyte injury induced by puromycin aminonucleoside in rodent models

Dihydroartemisinin selectively inhibits PDGFRα-positive ovarian cancer growth and metastasis through inducing degradation of PDGFRα protein

Evolution and Function of Dinosaur Teeth at Ultramicrostructural Level Revealed Using Synchrotron Transmission X-ray Microscopy

Apoptotic cell death in disease—Current understanding of the NCCD 2023

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