Nature Search

Plasma exchange and radiation resensitize immunotherapy-refractory melanoma: a phase I trial

Tumor-derived soluble PD-L1 drives immune checkpoint inhibitor (ICI) resistance and has recently been reported to be removed by therapeutic plasma exchange (TPE). Here, the authors report a phase I clinical trial investigating the combination of radiotherapy, TPE, and ICI rechallenge in patients with ICI-refractory metastatic melanoma with high PD-L1.

Jacob J. Orme
Henan Zhang
Sean S. Park
ResearchOpen Access13 Mar 2025
Nature Communications

Volume: 16, P: 1-11
Evolutionary analyses of the human genome

Wen-Hsiung Li
Zhenglong Gu
Anton Nekrutenko
Research15 Feb 2001
Nature

Volume: 409, P: 847-849
Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Fine-scale geospatial mapping of overweight and wasting (two components of the double burden of malnutrition) in 105 LMICs shows that overweight has increased from 5.2% in 2000 to 6.0% in children under 5 in 2017. Although overall wasting decreased over the same period, most countries are not on track to meet the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025.

Damaris K. Kinyoki
Jennifer M. Ross
Simon I. Hay
ResearchOpen Access20 Apr 2020
Nature Medicine

Volume: 26, P: 750-759
Malfunction of airway basal stem cells plays a crucial role in pathophysiology of tracheobronchopathia osteoplastica

Tracheobronchopathia osteoplastica (TO), is an underreported affliction characterized by squamous metaplasia and heterotopic bone formation in trachea and bronchi. Here the authors apply functional, as well as genome-wide transcriptional and epigenetic profiling to identify airway basal cells dysfunction underlying TO.

Yue Hong
Shan Shan
Tao Ren
ResearchOpen Access14 Mar 2022
Nature Communications

Volume: 13, P: 1-18
Gut microbiota promotes cholesterol gallstone formation by modulating bile acid composition and biliary cholesterol secretion

Metabolic conditions associated with alterations of the gut microbiome, such as obesity and diabetes, predispose to gallstone disease. Here the authors demonstrate that the gut microbiome, in particular the genus Desulfovibrionale, contribute to gallstone formation in mice.

Hai Hu
Wentao Shao
Aihua Gu
ResearchOpen Access11 Jan 2022
Nature Communications

Volume: 13, P: 1-13
Quantitative detection of nitric oxide in exhaled human breath by extractive electrospray ionization mass spectrometry

Susu Pan
Yong Tian
Huanwen Chen
ResearchOpen Access04 Mar 2015
Scientific Reports

Volume: 5, P: 1-5
Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD

Phosphodiesterase 4 inhibitors are under development as anti-inflammatory drugs, however, their mechanisms of action remain poorly understood. Komatsu et al. show that Rolipram, a specific inhibitor of PDE4, reduces inflammation in a model of middle ear infection by upregulating the deubiquitinase CYLD.

Kensei Komatsu
Ji-Yun Lee
Jian-Dong Li
ResearchOpen Access09 Apr 2013
Nature Communications

Volume: 4, P: 1-13
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.

Cristian Pattaro
Alexander Teumer
Caroline S. Fox
ResearchOpen Access21 Jan 2016
Nature Communications

Volume: 7, P: 1-19
Joint optic disk and cup segmentation for glaucoma screening using a region-based deep learning network

Feng Li
Wenjie Xiang
Haidong Zou
Research18 Apr 2022
Eye

Volume: 37, P: 1080-1087
Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Damaris K. Kinyoki
Jennifer M. Ross
Simon I. Hay
Amendments and CorrectionsOpen Access02 Jul 2020
Nature Medicine

Volume: 26, P: 1308
Berberine ameliorates blockade of autophagic flux in the liver by regulating cholesterol metabolism and inhibiting COX2-prostaglandin synthesis

Haidong Sun
Qian Liu
Aihua Gu
ResearchOpen Access01 Aug 2018
Cell Death & Disease

Volume: 9, P: 1-14
Autophagy Negatively Regulates Transmissible Gastroenteritis Virus Replication

Longjun Guo
Haidong Yu
Yue Wang
ResearchOpen Access31 Mar 2016
Scientific Reports

Volume: 6, P: 1-14
Conversion of steppe to cropland increases spatial heterogeneity of soil functional genes

Junjie Liu
Yaping Guo
Guanghua Wang
Research22 Aug 2023
The ISME Journal

Volume: 17, P: 1872-1883
Polymorphism rs2682818 participates in the progression of colorectal carcinoma via miR-618-TIMP1 regulatory axis

Wei Shao
Haina Xia
Youyou Zheng
ResearchOpen Access30 Nov 2021
Scientific Reports

Volume: 11, P: 1-11

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