USP35 regulates ferroptosis in ER+ breast cancer. USP35 interacts with, deubiquitinates, and stabilizes BRD4, which mediates USP35-induced upregulation of SLC7A11. This process inhibits ferroptosis and promotes the growth of ER+ breast cancer cells.
- Jiawei Cao
- Tao Wu
- Haihua Gu