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Showing 1–5 of 5 results
Advanced filters: Author: Haina Shin Clear advanced filters

  • Tissue-resident memory T cells are needed for optimal antiviral immunity at mucosal surfaces. Here the authors provide a mechanism for this protection, showing that vaginal CD301b+ DC-dependent IFN-γ production by CD8+ tissue-resident memory T cells, not circulating T cells, is central to HSV-2 resistance.

    • Haina Shin
    • Yosuke Kumamoto
    • Akiko Iwasaki
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • The inhibitory receptor programmed death-1 (PD-1) is upregulated on exhausted CD8+ T cells in HIV-infected individuals. Quigley et al. analyzed the transcriptional profile induced by PD-1 ligation and report that a transcription factor, BATF, is upregulated by PD-1 signaling and has a key role in PD-1–mediated inhibition of T cell function.

    • Michael Quigley
    • Florencia Pereyra
    • W Nicholas Haining
    Research
    Nature Medicine
    Volume: 16, P: 1147-1151

  • Tissue-resident memory T cells (TRM) are a new subset of memory cells that have been associated with enhanced protective immunity for their tissue of residence. A recent study by Jiang et al. sheds light on the migration behavior of TRM in both infected and unifected skin, and their ability to provide protection against re-infection even within a previously uninfected skin tissue.

    • Haina Shin
    • Akiko Iwasaki
    Research Highlights
    Cell Research
    Volume: 22, P: 1325-1327