Tumour cells can alter the function and metabolism of immune cells to reduce anti-tumour responses. Here the authors use single cell sequencing of HCC and show three tumour archetypes; metabolism, inflammation and stemness and the metabolism archetype are found in association with TREM+ macrophages which restrict immune cell infiltration into the tumour microenvironment.
- Tianhao Chu
- Guiqi Zhu
- Yinghong Shi
