Methods for asymmetric alkyl–alkyl bond formation between sp3-hybridized carbon atoms, C(sp3)–C(sp3), are limited yet highly desirable. Now an approach for asymmetric alkyl–alkyl bond formation by Ni-catalysed cross-coupling between alkenes has been developed to construct tertiary stereogenic carbon centres with head-to-tail regioselectivity and excellent chemo- and enantioselectivity.
- Peng-Fei Yang
- Han-Tong Zhao
- Wei Shu