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Showing 1–2 of 2 results
Advanced filters: Author: Hana Nuskova Clear advanced filters

  • S-acylation is the post-translational covalent attachment of fatty acids (FA) onto cysteines. Nuskova et al. find that exposure of cells to different FAs affects which FA is used to S-acylate GNAI proteins, thereby altering GNAI function and EGFR pathway activation, linking metabolism to signaling.

    • Hana Nůsková
    • Marina V. Serebryakova
    • Aurelio A. Teleman
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Blood supply to the heart is crucial for cardiac function. Here, the authors show that the mitochondrial tryptophanyl-tRNA synthetase, WARS2, drives blood vessel generation in zebrafish and rats and that inhibition of Wars2 diminishes blood vessel growth both within and outside in the heart, suggesting a new target for manipulating angiogenesis.

    • Mao Wang
    • Patrick Sips
    • Stuart A Cook
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12