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Showing 1–4 of 4 results
Advanced filters: Author: Hanane Boukarabila Clear advanced filters

  • The commitment stage at which progenitors seed the thymus remains unclear. Jacobsen and colleagues show that the earliest progenitors in the neonatal thymus have combined myeloid, T lymphocyte and B lymphocyte potential but not megakaryocyte-erythroid potential.

    • Sidinh Luc
    • Tiago C Luis
    • Sten Eirik W Jacobsen
    Research
    Nature Immunology
    Volume: 13, P: 412-419

  • The identity and lineage potential of the embryonic thymus-seeding progenitors that first seed the embryonic thymic rudiment is unclear. Jacobsen and colleagues find that these cells do not include multipotent stem cells or T cell–restricted progenitors but instead are lympho-myeloid progenitors.

    • Tiago C Luis
    • Sidinh Luc
    • Sten Eirik W Jacobsen
    Research
    Nature Immunology
    Volume: 17, P: 1424-1435

  • Analysis of transplantation of single haematopoietic stem cells in mice defines stable lineage-restricted fates in long-term self-renewing multipotent stem cells, including a class of multipotent stem cells that exclusively replenishes the megakaryocyte/platelet lineage.

    • Joana Carrelha
    • Yiran Meng
    • Sten Eirik W. Jacobsen
    Research
    Nature
    Volume: 554, P: 106-111

  • The identification of a functionally distinct subset of haematopoietic stem cells (HSCs) that is primed for platelet-specific gene expression is described; the cells frequently have long-term myeloid lineage bias, can self-renew and give rise to lymphoid-biased HSCs, and may enable the design of therapies for enhancing platelet reconstitution.

    • Alejandra Sanjuan-Pla
    • Iain C. Macaulay
    • Sten Eirik W. Jacobsen
    Research
    Nature
    Volume: 502, P: 232-236