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Bladder cancer variants share aggressive features including a CA125+ cell state and targetable TM4SF1 expression

Single cell analysis of histologic variant bladder tumors detects a shared CA125+ tumor cell state associated with aggressive clinical features and reveals enriched expression of TM4SF1, a membrane protein that can be targeted with CAR T cells.

Heiko Yang
Hanbing Song
Franklin W. Huang
ResearchOpen Access17 Jun 2025
Nature Communications

Volume: 16, P: 1-12
Single-cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient-specific tumor spheroids

The mechanisms of tumor heterogeneity in pediatric hepatoblastoma remain poorly characterized. Here, the authors perform single cell RNA sequencing and identify 5 signatures with distinct responses to chemotherapy using patient-derived hepatoblastoma spheroid cultures.

Hanbing Song
Simon Bucher
Bruce Wang
ResearchOpen Access25 Aug 2022
Nature Communications

Volume: 13, P: 1-15
Bulk RNA-seq of skeletal muscle reveals the role of ZBED6 in sepsis-induced muscle atrophy in minipigs

Huan Liu
Wen Shi
Ying Chen
ResearchOpen Access29 Jul 2025
Scientific Data

Volume: 12, P: 1-7
Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake

Insulin stimulates TUG cleavage to translocate GLUT4 and enhance glucose uptake. Here Bogan and colleagues show that the TUG cleavage product regulates thermogenic gene transcription, thereby coupling glucose uptake to organismal energy expenditure.

Estifanos N. Habtemichael
Don T. Li
Jonathan S. Bogan
Research08 Mar 2021
Nature Metabolism

Volume: 3, P: 378-393
Production of gas-releasing electrolyte-replenishing Ah-scale zinc metal pouch cells with aqueous gel electrolyte

The production of large-format aqueous Zn batteries is hindered by electrolyte consumption, hydrogen gas evolution and Zn dendrites growth during cycling. Here, the authors propose a specific pouch cell design capable of releasing hydrogen gas and refilling the electrolyte components.

Feifei Wang
Jipeng Zhang
Quan-Hong Yang
ResearchOpen Access14 Jul 2023
Nature Communications

Volume: 14, P: 1-10
Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states

The changes that prostate cancer (PCa) induces in its microenvironment are not fully understood. Here the authors use single-cell RNA-seq and organoids to characterise how the microenvironment responds to PCa, and also identify tumour-associated epithelial cell states and club cells.

Hanbing Song
Hannah N. W. Weinstein
Franklin W. Huang
ResearchOpen Access10 Jan 2022
Nature Communications

Volume: 13, P: 1-20
Kaempferol Identified by Zebrafish Assay and Fine Fractionations Strategy from Dysosma versipellis Inhibits Angiogenesis through VEGF and FGF Pathways

Fang Liang
Yuxiang Han
Song Li
ResearchOpen Access08 Oct 2015
Scientific Reports

Volume: 5, P: 1-10
Combinatory action of VEGFR2 and MAP kinase pathways maintains endothelial-cell integrity

Hanbing Zhong
Danyang Wang
Shuo Lin
Research22 Mar 2011
Cell Research

Volume: 21, P: 1080-1087
Publisher Correction: Cell types of origin of the cell-free transcriptome

Sevahn K. Vorperian
Mira N. Moufarrej
Stephen R. Quake
Amendments and CorrectionsOpen Access28 Mar 2022
Nature Biotechnology

Volume: 40, P: 974
Cell types of origin of the cell-free transcriptome

Cell types affected by various diseases are inferred from cell-free RNA.

Sevahn K. Vorperian
Mira N. Moufarrej
Stephen R. Quake
ResearchOpen Access07 Feb 2022
Nature Biotechnology

Volume: 40, P: 855-861

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Bladder cancer variants share aggressive features including a CA125+ cell state and targetable TM4SF1 expression

Single-cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient-specific tumor spheroids

Bulk RNA-seq of skeletal muscle reveals the role of ZBED6 in sepsis-induced muscle atrophy in minipigs

Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake

Production of gas-releasing electrolyte-replenishing Ah-scale zinc metal pouch cells with aqueous gel electrolyte

Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states

Kaempferol Identified by Zebrafish Assay and Fine Fractionations Strategy from Dysosma versipellis Inhibits Angiogenesis through VEGF and FGF Pathways

Combinatory action of VEGFR2 and MAP kinase pathways maintains endothelial-cell integrity

Publisher Correction: Cell types of origin of the cell-free transcriptome

Cell types of origin of the cell-free transcriptome

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