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Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia

When co-cultured with activated microglia, iPSC-derived interneurons from individuals with schizophrenia and from healthy controls show defects in metabolic pathways, but only the interneurons from individuals with schizophrenia showed prolonged metabolic deficits.

Gun-Hoo Park
Haneul Noh
Sangmi Chung
Research23 Oct 2020
Nature Neuroscience

Volume: 23, P: 1352-1364
Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell–derived cortical interneurons from subjects with schizophrenia

Shao et al. report that interneurons derived from iPSCs from schizophrenia patients have altered protocadherin expression and synaptic and arborization deficits. A PKC inhibitor, acting downstream of protocadherin, reversed the arborization deficit.

Zhicheng Shao
Haneul Noh
Sangmi Chung
Research21 Jan 2019
Nature Neuroscience

Volume: 22, P: 229-242
Correction: iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function

Peiyan Ni
Haneul Noh
Sangmi Chung
Amendments and Corrections31 Jul 2019
Molecular Psychiatry

Volume: 25, P: 3103-3104
iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function

Peiyan Ni
Haneul Noh
Sangmi Chung
Research24 Apr 2019
Molecular Psychiatry

Volume: 25, P: 2873-2888
Impact of schizophrenia GWAS loci converge onto distinct pathways in cortical interneurons vs glutamatergic neurons during development

Dongxin Liu
Amy Zinski
Sangmi Chung
Research14 Jun 2022
Molecular Psychiatry

Volume: 27, P: 4218-4233

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Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia

Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell–derived cortical interneurons from subjects with schizophrenia

Correction: iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function

iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function

Impact of schizophrenia GWAS loci converge onto distinct pathways in cortical interneurons vs glutamatergic neurons during development

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