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Advanced filters: Author: Hanna P. Roetschke Clear advanced filters

Protein degradation by human 20S proteasomes elucidates the interplay between peptide hydrolysis and splicing

Do proteasomes catalyze peptide splicing? Here, the authors develop and apply a method to identify spliced peptides produced from entire proteins, confirm that proteasomes produce a sizeable variety of cis-spliced peptides with well-defined characteristics, and show that non-spliced and spliced peptides are concentrated in hotspots.

Wai Tuck Soh
Hanna P. Roetschke
Michele Mishto
ResearchOpen Access07 Feb 2024
Nature Communications

Volume: 15, P: 1-25
A roadmap for ribosome assembly in human mitochondria

Lavdovskaia, Hanitsch, Linden et al. provide a comprehensive roadmap of mitoribosome biogenesis and establish that mitochondria use a unique pathway for the assembly of their translation machinery.

Elena Lavdovskaia
Elisa Hanitsch
Ricarda Richter-Dennerlein
ResearchOpen Access11 Jul 2024
Nature Structural & Molecular Biology

Volume: 31, P: 1898-1908
InvitroSPI and a large database of proteasome-generated spliced and non-spliced peptides

Hanna P. Roetschke
Guillermo Rodriguez-Hernandez
Juliane Liepe
ResearchOpen Access10 Jan 2023
Scientific Data

Volume: 10, P: 1-22
Large database for the analysis and prediction of spliced and non-spliced peptide generation by proteasomes

Gerd Specht
Hanna P. Roetschke
Juliane Liepe
ResearchOpen Access15 May 2020
Scientific Data

Volume: 7, P: 1-12

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