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Showing 1–3 of 3 results
Advanced filters: Author: Hanna Salmonowicz Clear advanced filters
  • During senescence, minority mitochondrial outer membrane permeabilization leads to the release of mtDNA into the cytosol through BAX and BAK macropores, in turn activating the cGAS–STING pathway, a major regulator of the senescence-associated secretory phenotype.

    • Stella Victorelli
    • Hanna Salmonowicz
    • João F. Passos
    ResearchOpen Access
    Nature
    Volume: 622, P: 627-636
  • Removal of senescent cells rejuvenates lungs of aged mice. Here the authors show that elimination of senescent cells using either genetic or pharmacological means improves lung function and physical health in a mouse model of idiopathic pulmonary fibrosis (IPF), suggesting potential therapy for treatment of human IPF.

    • Marissa J. Schafer
    • Thomas A. White
    • Nathan K. LeBrasseur
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11