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Showing 1–7 of 7 results
Advanced filters: Author: Hanna Vikkula Clear advanced filters

  • The role of androgen signalling in avian sexual development is still unclear. This study generated androgen receptor knockout chickens and find that, despite developing typical gonads, the males and females are infertile and many sexual ornaments and behaviors remain underdeveloped in both sexes.

    • Kamila Lengyel
    • Mekhla Rudra
    • Manfred Gahr
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • OTULIN is a deubiquitinase for linear ubiquitin chains. Here the authors show, using genetic mouse models and single-cell RNA-sequencing, that deficiency of OTULIN in keratinocytes causes skin inflammation and verrucous carcinoma via the induction of keratinocyte death, thereby implicating a function of OTULIN in keratinocyte homeostasis.

    • Esther Hoste
    • Kim Lecomte
    • Geert van Loo
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Van Loo and colleagues report that loss of the Zeb2 regulator of epithelial-to-mesenchymal transition from the intestinal epithelium leads to inflammation, increased intestinal permeability and colorectal cancer development, which is enhanced by the resident intestinal microbiome.

    • Karolina Slowicka
    • Ioanna Petta
    • Geert van Loo
    Research
    Nature Cancer
    Volume: 1, P: 620-634

  • Maintaining the intestinal barrier function requires a balance of multiple signalling pathways. Here the authors show that A20, an anti-inflammatory and anti-apoptotic protein, and Atg1611, an autophagy regulator, cross-regulate their respective protein levels and function to serve compensatory and redundant roles in fine-tuning gut barrier homeostasis.

    • Karolina Slowicka
    • Inmaculada Serramito-Gómez
    • Geert van Loo
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15