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Showing 1–2 of 2 results
Advanced filters: Author: Hannah E. Salapa Clear advanced filters

  • Oligodendrocyte (OL) injury and loss is a pathologic hallmark of multiple sclerosis. Here, the authors show the presence of stress granules in OLs in multiple sclerosis lesions, and their in vitro studies in human OLs indicate that stress granules formation is a response to a combination of metabolic stress and pro-inflammatory conditions.

    • Florian Pernin
    • Qiao-Ling Cui
    • Jack P. Antel
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • HnRNP A1 dysfunction is associated with neurodegeneration in multiple sclerosis (MS). Herein, advanced RNA sequencing and CLIPseq of MS brains and relevant models demonstrated that hnRNP A1 binding of target RNAs and RNA splicing were altered, precipitating neurodegeneration.

    • Hannah E. Salapa
    • Patricia A. Thibault
    • Michael C. Levin
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19