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Showing 1–6 of 6 results
Advanced filters: Author: Hannah Poisner Clear advanced filters

  • Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

    • Noah Sasa
    • Shohei Kojima
    • Yukinori Okada
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 65-79

  • A combined-ancestry GWAS of diabetic retinopathy, comprising 68,169 cases and 129,188 controls, revealed nine previously unreported loci associated with the condition, including an evolutionarily adaptive genetic variant alongside a potential functional mechanism that influences racial disparities in diabetes complications among individuals of non-Hispanic African ancestry.

    • Joseph H. Breeyear
    • Jacklyn N. Hellwege
    • Todd L. Edwards
    Research
    Nature Medicine
    Volume: 30, P: 2480-2488

  • Clonal hematopoiesis, which increases with age and is implicated in a variety of age-related diseases, is shown here to be associated with a greater risk of acute kidney injury and worse outcome following injury, as demonstrated using multiple patient cohorts, Mendelian randomization analysis and mechanistic studies in mouse disease models.

    • Caitlyn Vlasschaert
    • Cassianne Robinson-Cohen
    • Alexander G. Bick
    ResearchOpen Access
    Nature Medicine
    Volume: 30, P: 810-817

  • Here, the authors use passenger mutations to quantify expansion rate in ~6,000 people with mosaic chromosomal alterations in the NHLBI TOPMed cohort, finding associations between growth rate and blood counts along with germline genetic modulators of growth rate.

    • Yash Pershad
    • Taralynn Mack
    • Alexander G. Bick
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10

  • Genetic analyses of ancestrally diverse populations show evidence of heterogeneity across ancestries and provide insights into clinical implications, highlighting the importance of including ancestrally diverse populations to maximize genetic discovery and reduce health disparities.

    • Genevieve L. Wojcik
    • Mariaelisa Graff
    • Christopher S. Carlson
    Research
    Nature
    Volume: 570, P: 514-518