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Showing 1–3 of 3 results
Advanced filters: Author: Hannah Seferovic Clear advanced filters

  • Monoclonal antibodies and ligands targeting CD40 exhibit diverse agonistic and antitumor activities that are influenced by their design. Here, the authors identify mechanistic differences between clinically relevant anti-CD40 subclasses and CD40L, focusing on the dynamics and strengths of multi-bond formation at the single-molecule level.

    • Hannah Seferovic
    • Patricia Sticht
    • Peter Hinterdorfer
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Combining high-speed AFM, single molecule recognition force spectroscopy, and molecular dynamics simulations Zhu, Canena, Sikora et al. characterize the interaction dynamics of the trimeric spike protein of SARS-CoV-2 wt, and delta and omicron variants with its entry receptor ACE2. While delta variant increases avidity by multivalent binding to ACE2, omicron variant shows an extended binding lifetime.

    • Rong Zhu
    • Daniel Canena
    • Peter Hinterdorfer
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17