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Showing 1–13 of 13 results
Advanced filters: Author: Hannes Stockinger Clear advanced filters

  • Co-patterning of a membrane protein bait and a fluorescently labeled prey is used to examine protein-protein interactions in a semiautomated fashion in living cells. Photobleaching experiments and single-molecule imaging further allow dynamic studies of the interaction.

    • Michaela Schwarzenbacher
    • Martin Kaltenbrunner
    • Gerhard J Schütz
    Research
    Nature Methods
    Volume: 5, P: 1053-1060

  • Although γδ T cells are known to participate in immune dysregulation in solid tumors, their relevance to human microsatellite-stable (MSS) colorectal cancer (CRC) is less well-studied. Here, using single-cell RNA-sequencing, the authors identify a Vδ1 + T cell subset, which are functionally impaired in MSS CRC via a TIGIT-NECTIN2 interaction.

    • Victoria Stary
    • Ram V. Pandey
    • Nina Pilat
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Determining molecular clustering in Photoactivated Localization Microscopy (PALM) experiments requires knowledge of the blinking properties of the fluorophore to prevent overcounting artefacts. Here the authors develop an experimental and analytical framework to determine the blinking parameters of fluorophores and incorporate this information into cluster analysis.

    • René Platzer
    • Benedikt K. Rossboth
    • Mario Brameshuber
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Mechanical forces acting on ligand-engaged T-cell receptors (TCRs) have previously been implicated in T-cell antigen recognition, yet their sensitivity and specificity are still poorly defined. Here, authors report a FRET-based sensor that informs directly on the magnitude and kinetics of TCR-imposed forces at the single molecule level.

    • Janett Göhring
    • Florian Kellner
    • Gerhard J. Schütz
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Higher-order TCRs have been postulated to maintain high antigen sensitivity and trigger signaling. Huppa and colleagues use various investigative techniques and find exclusively monomeric TCR–CD3 complexes that drive the recognition of antigenic pMHC.

    • Mario Brameshuber
    • Florian Kellner
    • Johannes B. Huppa
    Research
    Nature Immunology
    Volume: 19, P: 487-496

  • Boztug and colleagues identify an immunodeficient patient with a deficiency in the guanine-nucleotide-exchange factor RASGRP1. They find that human RASGRP1 is important for the function of T cells, B cells and NK cells and that it has a role in the regulation of the cytoskeleton.

    • Elisabeth Salzer
    • Deniz Cagdas
    • Kaan Boztug
    Research
    Nature Immunology
    Volume: 17, P: 1352-1360

  • PALM and STORM are powerful methods for studying membrane-protein clustering. However, fluorophore blinking can lead to miscounting artifacts. A new method shows that varying label density works for artifact-free analysis of membrane-protein nanoclusters.

    • Florian Baumgart
    • Andreas M Arnold
    • Gerhard J Schütz
    Research
    Nature Methods
    Volume: 13, P: 661-664

  • Huppa and colleagues highlight signaling deficiencies in chimeric antigen receptor (CAR)-modified T cells that limit the efficacy of CAR T cell therapies to target tumors with diminished antigen expression.

    • Venugopal Gudipati
    • Julian Rydzek
    • Johannes B. Huppa
    Research
    Nature Immunology
    Volume: 21, P: 848-856

  • Brell, Berg et al find that iron enters cells not only through iron-transferrin uptake by the transferrin receptor (CD71) but also through uptake of heme-albumin by this receptor and that heme-albumin stimulates proliferation in a manner dependent on heme oxygenase 1. This study presents a new route for iron uptake in mammalian cells.

    • Brell Jennifer
    • Verena Berg
    • Johannes Stöckl
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-13

  • Wagner et al. carry out a longitudinal seroepidemiological study of SARS-CoV-2 antibodies in a cohort of adults from a large company in Vienna, Austria. In individuals positive for S1-reactive antibodies at baseline, RBD-specific antibodies are most likely to persist for six months and correlate most closely with SARS-CoV-2 neutralizing ability.

    • Angelika Wagner
    • Angela Guzek
    • Ursula Wiedermann
    ResearchOpen Access
    Communications Medicine
    Volume: 1, P: 1-11