This study shows that restoring mitochondrial respiration in atherosclerotic macrophages reopens their chromatin, enabling phenotype reprogramming. Using targeted liposomes to deliver miR-10a, researchers successfully reduced atherosclerosis in mice by reprogramming macrophage phenotypes. The findings offer a promising epigenetic therapy for atherosclerosis
- Fei Fang
- Erxiang Wang
- Xiaoheng Liu
