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Showing 1–11 of 11 results
Advanced filters: Author: Hanrui Zhang Clear advanced filters

  • Excessive apoptotic cell death and defective efferocytosis drive loss of tolerance and autoimmunity; however, a direct role for macrophage-specific defects in autoimmunity is underexplored. Here, the authors identify macrophage WDFY3 as a negative regulator of autoimmunity by enhancing efferocytosis and reducing MHC-II-mediated antigen presentation, T cell activation, and cytokine dysregulation.

    • Xun Wu
    • Ziyi Wang
    • Hanrui Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Sustainable harvesting of lithium is critical to the success of the entire battery industry. Here, the authors report an electrochemical leaching method which can directly extract lithium from natural state spodumene ores with low energy consumption, environmental impact, and high efficiency.

    • Hanrui Zhang
    • Ying Han
    • Feifei Shi
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • New research in this issue of Nature Metabolism shows how a high-protein diet increases amino acids in blood and atherosclerotic plaques, and in plaque macrophages activates mTOR signalling, suppresses mitophagy and increases apoptosis, thereby exacerbating atherosclerotic-plaque build-up in genetically modified mouse models.

    • Hanrui Zhang
    • Muredach P. Reilly
    News & Views
    Nature Metabolism
    Volume: 2, P: 7-8

  • DNA damage is a key component of many cancer therapies. Here, the authors utilised a dose-response combination screen of ATR, ATM and DNA-PK inhibitors, and identified combination treatments that achieves high combinatorial efficacy and synergy.

    • Hanrui Zhang
    • Julian Kreis
    • Yuanfang Guan
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-8

  • Efferocytosis describes the engulfment and clearance of apoptotic cells by phagocytes. Here the authors identify in primary mouse macrophage WDFY3 as a regulator for efferocytosis, in which c-terminal WDFY3 is sufficient to modulate degradation while full-length WDFY3 is required to modulate the uptake of apoptotic cells.

    • Jianting Shi
    • Xun Wu
    • Hanrui Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19

  • Ocean eddies are known to induce global heat transport but how this is influenced by their shape is unknown. Here the authors combine in-situ drifter and satellite data to show that eddy-induced heat transport can be doubled due to their elongated shape.

    • Hailin Wang
    • Bo Qiu
    • Zhengguang Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-10

  • Deng et al. develop deep learning methods that identify Parkinson’s Disease (PD) patients using public accelerometer and position data with higher accuracy than when using gait/rest and voice-based models. Their study demonstrates the complementary predictive power of tapping, gait/rest and voice data and establishes integrative deep learning-based models for identifying PD.

    • Kaiwen Deng
    • Yueming Li
    • Yuanfang Guan
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-10