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Advanced filters: Author: Hans-Heinrich Kreipe Clear advanced filters
  • In congenital neutropenia, myeloid-lineage differentiation in response to the cytokine G-CSF is defective. Julia Skokowa et al. now show that an interplay among three proteins—the adapter proteins HCLS1 and HAX1 and the transcription factor LEF-1—is required for G-CSF–triggered granulocytic differentiation, and they provide evidence that this pathway is dysregulated in both congenital neutropenia and acute myeloid leukemia.

    • Julia Skokowa
    • Maxim Klimiankou
    • Karl Welte
    Research
    Nature Medicine
    Volume: 18, P: 1550-1559