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Showing 1–2 of 2 results
Advanced filters: Author: Hans-Peter Raué Clear advanced filters
  • For years, manufacturers have used one of only two chemicals to inactivate viruses for vaccine production: formaldehyde or β-propiolactone, and formaldehyde can damage key antigenic epitopes, leading to reduced immunogenicity or exacerbated disease. Ian Amanna and his colleagues have now found a third, the oxidizing agent hydrogen peroxide (H2O2), which they show can be more effective than the conventional approaches. Utility of the H2O2-based approach is demonstrated in three model systems.

    • Ian J Amanna
    • Hans-Peter Raué
    • Mark K Slifka
    Research
    Nature Medicine
    Volume: 18, P: 974-979