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Showing 1–4 of 4 results
Advanced filters: Author: Hans-Rudolf Hotz Clear advanced filters

  • DNA methylation is an epigenetic mark directing stable, heritable gene silencing through development. A new study uncovers the importance of demethylation of the DNA methyltransferase-1 for maintenance of DNA methylation.

    • Hans-Rudolf Hotz
    • Antoine H F M Peters
    News & Views
    Nature Genetics
    Volume: 41, P: 10-11

  • HP1 proteins bind methylated histone H3 Lys9, a hallmark of heterochromatin, and mediate heterochromatin spreading by recruiting histone methyltransferase activities. New studies have now identified a long noncoding RNA called BORDERLINE that prevents spreading of the HP1 protein Swi6 and histone H3 Lys9 methylation beyond the pericentromeric repeat region of fission yeast chromosome 1.

    • Claudia Keller
    • Raghavendran Kulasegaran-Shylini
    • Marc Bühler
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 994-1000