Nature Search

ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L

Lineage tracing in mice identifies a subpopulation of basal cells that express Tmprss2 and Nkx3 as the origin of ERG-driven prostate cancer. Upon expansion, these cells show an enrichment for STAT3 chromatin binding and elevated expression of KMT2A and DOT1L as dependencies for ERG oncogenicity.

Weiran Feng
Erik Ladewig
Charles L. Sawyers
ResearchOpen Access26 Aug 2025
Nature Genetics

Volume: 57, P: 2177-2191
A human-specific enhancer fine-tunes radial glia potency and corticogenesis

HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence between cortical regions through amplified WNT signalling.

Jing Liu
Federica Mosti
Debra L. Silver
Research14 May 2025
Nature

Volume: 643, P: 1321-1332
Genome-wide associated study identifies NAC42-activated nitrate transporter conferring high nitrogen use efficiency in rice

Improving crop nitrogen use efficiency can facilitate sustainable production, however, the genetic mechanisms have not been fully revealed. Here, the authors discover the NAC42-NPF6.1 signaling cascade mainly derives from indica and wild rice and demonstrate the potential of using the allele for cultivar improvement.

Weijie Tang
Jian Ye
Jianmin Wan
ResearchOpen Access21 Nov 2019
Nature Communications

Volume: 10, P: 1-11
Author Correction: A human-specific modifier of cortical connectivity and circuit function

Ewoud R. E. Schmidt
Hanzhi T. Zhao
Franck Polleux
Amendments and Corrections06 Jan 2022
Nature

Volume: 601, P: E10
Protectin DX restores Treg/T_h17 cell balance in rheumatoid arthritis by inhibiting NLRP3 inflammasome via miR-20a

Shengwei Jin
Siyuan Sun
Jianguang Wang
ResearchOpen Access15 Mar 2021
Cell Death & Disease

Volume: 12, P: 1-11
TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential

TrkH is a bacterial ion channel that is regulated by nucleotides and its associated protein TrkA. Here the authors present ADP and ATP bound TrkH-TrkA structures, which reveal the mechanism for the transmission of nucleotide-induced conformational changes in TrkA to the opening of the TrkH channel and further support the proposed gating mechanism with functional studies.

Hanzhi Zhang
Yaping Pan
Ming Zhou
ResearchOpen Access28 Jan 2020
Nature Communications

Volume: 11, P: 1-11
Supramolecular trap for catching polyamines in cells as an anti-tumor strategy

Polyamines are essential for cell growth and are frequently increased in concentration in cancer cells. Here, the authors use a macrocycle to generate a supramolecular trap, which depletes the polyamines in cells, induces apoptosis and reduces cancer cell growth in mice.

Junyi Chen
Hanzhi Ni
Chunju Li
ResearchOpen Access07 Aug 2019
Nature Communications

Volume: 10, P: 1-8
High-speed light-sheet microscopy for the in-situ acquisition of volumetric histological images of living tissue

Benchtop and miniaturized microscopes leveraging single-objective light-sheet illumination allow for volumetric histological imaging of living tissue, in real time and without the need for tissue staining or excision.

Kripa B. Patel
Wenxuan Liang
Elizabeth M. C. Hillman
Research28 Mar 2022
Nature Biomedical Engineering

Volume: 6, P: 569-583
A human-specific modifier of cortical connectivity and circuit function

The human-specific gene duplication SRGAP2C is identified as a modifier of structural and functional features of cortical circuits leading to improved behavioural performance that may have allowed the emergence of cognitive properties characterizing the human brain.

Ewoud R. E. Schmidt
Hanzhi T. Zhao
Franck Polleux
Research27 Oct 2021
Nature

Volume: 599, P: 640-644
Promoting carbon neutrality and green growth through cultural industry financing

Hanzhi Zhang
Jingfeng Zhang
Chih-Hung Pai
ResearchOpen Access06 Jan 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-8
Difference in light use strategy in red alga between Griffithsia pacifica and Porphyridium purpureum

Mingyuan Xie
Wenjun Li
Fuli Zhao
ResearchOpen Access13 Jul 2021
Scientific Reports

Volume: 11, P: 1-9
Secreted KIAA1199 promotes the progression of rheumatoid arthritis by mediating hyaluronic acid degradation in an ANXA1-dependent manner

Wei Zhang
Guoyu Yin
Xinyu Yang
ResearchOpen Access20 Jan 2021
Cell Death & Disease

Volume: 12, P: 1-14
The spontaneous differentiation and chromosome loss in iPSCs of human trisomy 18 syndrome

Ting Li
Hanzhi Zhao
Dongmei Lai
ResearchOpen Access26 Oct 2017
Cell Death & Disease

Volume: 8, P: e3149
Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes

Hui Yang
Zhen Liu
Jinsong Li
ResearchOpen Access16 Jul 2013
Cell Research

Volume: 23, P: 1187-1200

Search

ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L

A human-specific enhancer fine-tunes radial glia potency and corticogenesis

Genome-wide associated study identifies NAC42-activated nitrate transporter conferring high nitrogen use efficiency in rice

Author Correction: A human-specific modifier of cortical connectivity and circuit function

Protectin DX restores Treg/T_h17 cell balance in rheumatoid arthritis by inhibiting NLRP3 inflammasome via miR-20a

TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential

Supramolecular trap for catching polyamines in cells as an anti-tumor strategy

High-speed light-sheet microscopy for the in-situ acquisition of volumetric histological images of living tissue

A human-specific modifier of cortical connectivity and circuit function

Promoting carbon neutrality and green growth through cultural industry financing

Difference in light use strategy in red alga between Griffithsia pacifica and Porphyridium purpureum

Secreted KIAA1199 promotes the progression of rheumatoid arthritis by mediating hyaluronic acid degradation in an ANXA1-dependent manner

The spontaneous differentiation and chromosome loss in iPSCs of human trisomy 18 syndrome

Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes

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