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Showing 1–3 of 3 results

Advanced filters: Author: Haofei Miao Clear advanced filters

Slipknot-gauged mechanical transmission and robotic operation

A mechano-intelligent transmission mechanism based on the slipknot delivers precise force signals for clinical practice and robotic operations such as minimally invasive surgery and tendon-driven robotics.

Yaoting Xue
Jiasheng Cao
Xiujun Cai
ResearchOpen Access26 Nov 2025
Nature

Volume: 647, P: 889-896
VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer

The Wnt/β-catenin and YAP signaling pathways have fundamental roles in cancer. Here, the authors show that VGLL4, a known YAP antagonist, also negatively regulates Wnt/β-catenin signaling by targeting TEAD-DNA-TCF4 complex, thereby inhibiting colorectal cancer growth.

Shi Jiao
Chuanchuan Li
Zhaocai Zhou
ResearchOpen Access04 Jan 2017
Nature Communications

Volume: 8, P: 1-13
Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction

A small-molecule activator of Wnt/β-catenin signaling acts by binding a negative regulator of β-catenin, Axin, leading to a conformational change that promotes association of Axin with LRP6.

Sheng Wang
Junlin Yin
Lin Li
Research28 Jul 2013
Nature Chemical Biology

Volume: 9, P: 579-585