Nature Search

Covariation MS uncovers a protein that controls cysteine catabolism

A mass spectrometry-based approach globally identifies protein regulators of metabolism and reveals the role of LRRC58 in controlling cysteine catabolism.

Haopeng Xiao
Martha Ordonez
Edward T. Chouchani
ResearchOpen Access17 Sept 2025
Nature

P: 1-9
Self-assembly of peptide nanocapsules by a solvent concentration gradient

Biobased materials are of interest for many applications. Here the authors report insect-derived peptides that self-assemble into hollow nanocapsules through a gradient-driven, single-step, solvent exchange process, enabling the encapsulation of diverse cargoes with potential for drug delivery applications.

Haopeng Li
Xuliang Qian
Jing Yu
Research26 Apr 2024
Nature Nanotechnology

Volume: 19, P: 1141-1149
A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding

Insulin secretion adapts to metabolic needs, but how this happens over the short term is not clear. Here the authors show this involves upregulation of beta-cell exocytosis and requires the SUMO-protease SENP1, which responds to redox state in a zinc-dependent manner.

Haopeng Lin
Kunimasa Suzuki
Patrick E. MacDonald
ResearchOpen Access06 Jan 2024
Nature Communications

Volume: 15, P: 1-15
Author Correction: Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion

Doan C. Nguyen
Swetha Garimalla
F. Eun-Hyung Lee
Amendments and CorrectionsOpen Access17 Jan 2019
Nature Communications

Volume: 10, P: 1
An enrichment method based on synergistic and reversible covalent interactions for large-scale analysis of glycoproteins

Understanding the functions of protein glycosylation critically depends on methods to efficiently enrich glycoproteins from complex samples. Here, the authors develop a strategy using dendrimer-conjugated benzoboroxole to enhance glycopeptide enrichment, providing the basis for more comprehensive glycoprotein analyses.

Haopeng Xiao
Weixuan Chen
Ronghu Wu
ResearchOpen Access27 Apr 2018
Nature Communications

Volume: 9, P: 1-12
Monocarboxylate transporters facilitate succinate uptake into brown adipocytes

In the context of succinate uptake to promote adipose tissue browning, Reddy, Winther et al. show how the directionality of succinate transport across membranes is coupled with metabolic flux-derived changes in pH gradients.

Anita Reddy
Sally Winther
Edward T. Chouchani
Research20 Feb 2024
Nature Metabolism

Volume: 6, P: 567-577
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor

A first-in-class covalent inhibitor of creatine phosphagen energetics was developed that induced toxicity in creatine kinase-dependent AML cell lines and regulated proinflammatory cytokine production in macrophages.

Narek Darabedian
Wenzhi Ji
Edward T. Chouchani
Research23 Feb 2023
Nature Chemical Biology

Volume: 19, P: 815-824
Lactate regulates cell cycle by remodelling the anaphase promoting complex

Discovery of a biochemical mechanism through which lactate binds and inhibits the SUMO protease SENP1, stimulating timed degradation of cell cycle proteins, and resulting in mitotic exit.

Weihai Liu
Yun Wang
Edward T. Chouchani
Research15 Mar 2023
Nature

Volume: 616, P: 790-797
Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes

Increased glycogen metabolism in adipocytes leads to expression of uncoupling protein 1, thereby linking glucose metabolism to thermogenesis.

Omer Keinan
Joseph M. Valentine
Alan R. Saltiel
Research27 Oct 2021
Nature

Volume: 599, P: 296-301
UCP1 governs liver extracellular succinate and inflammatory pathogenesis

UCP1 is exclusively expressed in brown and beige adipocytes, where it drives thermogenesis through futile substrate cycling. Mills et al. identify a endocrine pathway mediated by the UCP1 catabolic circuit that antagonizes liver inflammation by lowering the concentration of succinate in the liver extracellular fluid.

Evanna L. Mills
Cathal Harmon
Edward T. Chouchani
Research17 May 2021
Nature Metabolism

Volume: 3, P: 604-617
Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion

Antibody-secreting cells (ASC) such as plasma cells must migrate to the bone marrow to survive, but microniche elements that promote survival are unknown. Here the authors define specific factors from the microniche that can maintain ASC in vitro for over 50 days, involving MSC secretome proteins, APRIL, and hypoxic conditions.

Doan C. Nguyen
Swetha Garimalla
F. Eun-Hyung Lee
ResearchOpen Access12 Sept 2018
Nature Communications

Volume: 9, P: 1-12
Dynamic regulation of CD28 conformation and signaling by charged lipids and ions

CD28 signaling motifs are sequestered within the membrane via interactions with phospholipids. TCR activation increases the local Ca²⁺ concentration, which disrupts CD28-lipid interactions.

Wei Yang
Weiling Pan
Chenqi Xu
Research23 Oct 2017
Nature Structural & Molecular Biology

Volume: 24, P: 1081-1092
AIDA and UCP1 snuggle up to prevent hypothermia

In response to cold stress, mammals release norepinephrine from the sympathetic nervous system to elevate thermogenesis in brown adipose tissue (BAT) in order to maintain body temperature. This study reveals that the protein AIDA connects sympathetic input, reactive oxygen species, and uncoupling protein 1-mediated adaptive thermogenesis in BAT.

Evanna L. Mills
Haopeng Xiao
Edward T. Chouchani
News & Views09 Mar 2021
Nature Cell Biology

Volume: 23, P: 216-218
A phenotype-based AI pipeline outperforms human experts in differentially diagnosing rare diseases using EHRs

Xiaohao Mao
Yu Huang
Ting Chen
ResearchOpen Access28 Jan 2025
npj Digital Medicine

Volume: 8, P: 1-15
PINX1 loss confers susceptibility to PARP inhibition in pan-cancer cells

Mei Huang
Xiaotong Zhu
Yu Wang
ResearchOpen Access22 Aug 2024
Cell Death & Disease

Volume: 15, P: 1-15
Evidence for the importance of post-transcriptional regulatory changes in ovarian cancer progression and the contribution of miRNAs

Mengnan Zhang
Lilya V. Matyunina
John F. McDonald
ResearchOpen Access15 Aug 2017
Scientific Reports

Volume: 7, P: 1-9

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