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Advanced filters: Author: Haoxing Zhao Clear advanced filters

Cryo-EM reveals cholesterol binding in the lysosomal GPCR-like protein LYCHOS

LYCHOS is a lysosome-localized cholesterol sensor involved in mTORC1 activity regulation. Here, the authors report the three-dimensional structure of LYCHOS bound to cholesterols, revealing the recognition mechanism for this molecule.

Jie Zhao
Qingya Shen
Wei Yan
Research17 Jan 2025
Nature Structural & Molecular Biology

Volume: 32, P: 896-904
Lymphatic endothelial-like cells promote glioblastoma stem cell growth through cytokine-driven cholesterol metabolism

Rich and colleagues identify that lymphatic endothelial-like cells in glioblastoma drive the growth of cancer stem cells via CCL21–CCR7 signaling, inducing KAT5 to acetylate HMGSC1, which enhances its protein stability and cholesterol synthesis.

Linjie Zhao
Zhixin Qiu
Jeremy N. Rich
Research03 Jan 2024
Nature Cancer

Volume: 5, P: 147-166
Training to improve contrast sensitivity in amblyopia: correction of high-order aberrations

Meng Liao
Haoxing Zhao
Yifeng Zhou
ResearchOpen Access18 Oct 2016
Scientific Reports

Volume: 6, P: 1-8