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Showing 1–9 of 9 results
Advanced filters: Author: Harding Rosalind M. Clear advanced filters

  • Neutralizing nanobodies (Nb) are of considerable interest as therapeutic agents for COVID-19 treatment. Here, the authors functionally and structurally characterize Nbs that bind with high affinity to the receptor binding domain of the SARS-CoV-2 spike protein and show that an engineered homotrimeric Nb prevents disease progression in a Syrian hamster model of COVID-19 when administered intranasally.

    • Jiandong Huo
    • Halina Mikolajek
    • Raymond J. Owens
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768

  • Peter Donnelly and colleagues report sequencing of 62 pneumococcal isolates sampled from a CDC surveillance program. They characterize five independent instances of vaccine escape recombination through capsular switches, providing insight into the role of recombination in remodeling pneumococcal genomes under selective pressure and in the population dynamics of this pathogen.

    • Tanya Golubchik
    • Angela B Brueggemann
    • Rory Bowden
    Research
    Nature Genetics
    Volume: 44, P: 352-355

  • Paul Boutros, Robert Bristow and colleagues report a molecular analysis of the spatial heterogeneity of clinically localized, multifocal prostate cancer. They find that multifocal tumors are highly heterogeneous, and they identify a novel recurrent amplification of MYCL1.

    • Paul C Boutros
    • Michael Fraser
    • Robert G Bristow
    Research
    Nature Genetics
    Volume: 47, P: 736-745

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103