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Showing 1–11 of 11 results
Advanced filters: Author: Harmit S. Malik Clear advanced filters

  • Centromeric DNA repeats can be thought of as selfish elements that constantly compete to beat the odds and make it into the egg at meiosis.

    • Steven Henikoff
    • Harmit S. Malik
    Comments & Opinion
    Nature
    Volume: 417, P: 227

  • A diverse range of pathogens produce molecules that mimic host cell components to subvert host cell functions. Elde and Malik highlight the various types of mimicry used by pathogens and the measures that host cells use to counteract the mimics' effects.

    • Nels C. Elde
    • Harmit S. Malik
    Reviews
    Nature Reviews Microbiology
    Volume: 7, P: 787-797

  • Short H2A variants are testis-specific histones that destabilize nucleosomes during spermatogenesis. In this study, the authors show that these variants are expressed in an array of different cancers and identify splicing changes associated with nucleosome instability in these malignancies.

    • Guo-Liang Chew
    • Marie Bleakley
    • Jay Sarthy
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • A human–SARS-CoV-2 protein interaction map highlights cellular processes that are hijacked by the virus and that can be targeted by existing drugs, including inhibitors of mRNA translation and predicted regulators of the sigma receptors.

    • David E. Gordon
    • Gwendolyn M. Jang
    • Nevan J. Krogan
    Research
    Nature
    Volume: 583, P: 459-468

  • Here, Hiatt et al. report the knock-out of over 400 genes in primary CD4+ T cells to assess their functional role in HIV replication, finding 86 initial candidates of which 47 are validated as HIV host factors, including 23 with restrictive activity.

    • Joseph Hiatt
    • Judd F. Hultquist
    • Nevan J. Krogan
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Documented cases of horizontal gene transfer from bacteria to eukaryotes are rare, but now, not only is a new class of transferred genes identified, the function of one representative is also demonstrated in its new setting, where it controls bacterial growth.

    • Seemay Chou
    • Matthew D. Daugherty
    • Joseph D. Mougous
    Research
    Nature
    Volume: 518, P: 98-101

  • This paper documents the evolutionary interaction between the innate immunity gene protein kinase R (PKR), its substrate elF2α, and its poxvirus mimic K3L. It is concluded that the rapid evolution of the PKR gene may be due to viral mimicry.

    • Nels C. Elde
    • Stephanie J. Child
    • Harmit S. Malik
    Research
    Nature
    Volume: 457, P: 485-489

  • Transposable elements (TEs) are widely known for their deleterious consequences of selfish propagation and mutagenesis. However, as described in this Review, TEs also provide hosts with rich, beneficial gene-regulatory machinery in the form of regulatory DNA elements and TE-derived gene products. The authors highlight the diverse regulatory contributions of TEs to organismal physiology and pathology, provide a framework for responsibly assigning functional roles to TEs and offer visions for the future.

    • Edward B. Chuong
    • Nels C. Elde
    • Cédric Feschotte
    Reviews
    Nature Reviews Genetics
    Volume: 18, P: 71-86