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Nature Cell Biology (1)

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A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression

Verginadis et al. show that ATF4 regulates Col1a1 expression and collagen biosynthesis in perivascular cancer-associated fibroblasts, thereby supporting angiogenesis and progression in melanoma and pancreatic cancer.

Ioannis I. Verginadis
Harris Avgousti
Constantinos Koumenis
ResearchOpen Access02 Jun 2022
Nature Cell Biology

Volume: 24, P: 940-953

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A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression

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