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Showing 1–3 of 3 results
Advanced filters: Author: Harumi Fukada Clear advanced filters

  • Ubiquitin is a stable and soluble protein, but it is commonly found in inclusion bodies in neurodegenerative disorders and cancer. Here, Morimoto et al. report that increasing ubiquitin chain length leads to the formation of amyloid-like fibrils, which are degraded by an autophagy mechanism.

    • Daichi Morimoto
    • Erik Walinda
    • Masahiro Shirakawa
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10

  • Dendrimers are attractive polymers with a well-defined structure and multivalent terminal groups. We have designed a novel type of peptidomimetic based on dendrimer by modifying the amino acids at the periphery of the dendrimer. The dendritic peptidomimetic containing Pro and Arg was bound to a model protein, amphiphysin II SH3 domain, at a similar level to a model binding peptide, a Pro-rich sequence of dynamin.

    • Chie Kojima
    • Harumi Fukada
    • Takashi Inui
    Research
    Polymer Journal
    Volume: 45, P: 339-345