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Showing 1–6 of 6 results
Advanced filters: Author: Hashem Koohy Clear advanced filters
  • Koohy and co-workers discuss how we must turn to machine-learning approaches to define the antigen specificity of the many millions of possible T cell receptors. They review the models and methods currently being used to predict cognate antigens for orphan T cell receptors.

    • Dan Hudson
    • Ricardo A. Fernandes
    • Hashem Koohy
    Reviews
    Nature Reviews Immunology
    Volume: 23, P: 511-521
  • Multimodal single-cell profiling reveals heterogeneity of colonic CD8+ T cells in patients with ulcerative colitis, including expansion of a chronically activated IL-26-expressing subpopulation with innate-like features.

    • Daniele Corridoni
    • Agne Antanaviciute
    • Alison Simmons
    Research
    Nature Medicine
    Volume: 26, P: 1480-1490
  • Profiling of single epithelial cells in healthy and inflamed colons identifies specialized cellular subpopulations, including a type of goblet cell that secretes the antibacterial protein WFDC2, which preserves the integrity of the epithelial barrier layer.

    • Kaushal Parikh
    • Agne Antanaviciute
    • Alison Simmons
    Research
    Nature
    Volume: 567, P: 49-55
  • Aulicino, Antanaviciute et al investigate the transcriptional response to invasive Salmonella strains in dendritic cells (DCs). They show that S. Typhi mount a response against nitrosative stress pathways and propose a role of iron uptake and transport in preventing infection, which the pathogen can bypass. In parallel, they find that invasive Salmonella employs several mechanisms targeting more classic aspects of immunity to impair DC function.

    • Anna Aulicino
    • Agne Antanaviciute
    • Alison Simmons
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-17