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Showing 1–4 of 4 results
Advanced filters: Author: Hassina Benchabane Clear advanced filters

  • Wnt receptors are controlled by their ubiquitin-mediated proteolysis. The authors show that the USP46 deubiquitylase complex potentiates Wnt signaling in human cells, Xenopus, and zebrafish by inhibiting cell surface LRP6 degradation.

    • Victoria H. Ng
    • Zachary Spencer
    • Ethan Lee
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Cereblon (CRBN) is an E3 ubiquitin ligase substrate receptor that is involved in cancer cell death, although its regulation is poorly understood. Here, the authors show that Wnt ligand increases CRBN-dependent protein degradation and demonstrate CRBN’s importance in physiological Wnt signaling.

    • Chen Shen
    • Anmada Nayak
    • David J. Robbins
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Wnt/β-catenin signalling directs several developmental processes and is aberrantly activated in several cancers. Here the authors implicate Tankyrase—previously shown to target the scaffolding protein Axin for proteolysis—in early Wnt signalling by promoting the interaction between Axin and the Wnt co-receptor LRP6.

    • Eungi Yang
    • Ofelia Tacchelly-Benites
    • Yashi Ahmed
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14