Nature Search

Gtf2i-encoded transcription factor Tfii-i regulates myelination via Sox10 and Mbp regulatory elements

The transcriptional regulation of oligodendrocytes has an essential role in myelin formation and maintenance. Here, the authors identify the transcription factor Tfii-i as a regulator of myelin genes expression in the nervous system and show that its loss enhances myelin thickness and nerve conduction.

Gilad Levy
May Rokach
Boaz Barak
ResearchOpen Access26 Sept 2025
Nature Communications

Volume: 16, P: 1-24
CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves

Myelinating cells differentially myelinate axons of different diameters, however whether they can also restrict radial axonal growth remained unclear. Here, the authors show that CMTM6 in Schwann cells restricts axon diameters, affecting sensory nerve conduction and behavioral performance.

Maria A. Eichel
Vasiliki-Ilya Gargareta
Hauke B. Werner
ResearchOpen Access09 Sept 2020
Nature Communications

Volume: 11, P: 1-12
Oligodendrocyte–axon metabolic coupling is mediated by extracellular K⁺ and maintains axonal health

Looser et al. reveal that oligodendrocytes detect and respond to axonal activity using K⁺ signaling to regulate vital metabolic support and maintain axon health.

Zoe J. Looser
Zainab Faik
Aiman S. Saab
ResearchOpen Access24 Jan 2024
Nature Neuroscience

Volume: 27, P: 433-448
Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia

Johannes Schumacher and colleagues report the results of a genetic association study of idiopathic achalasia, a rare motility disorder of the esophagus. They show that common variation in the HLA-DQ region is strongly associated with achalasia risk, implicating immune-mediated processes in this disorder.

Ines Gockel
Jessica Becker
Johannes Schumacher
Research06 Jul 2014
Nature Genetics

Volume: 46, P: 901-904
Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system

Fibrocytes are monocyte-derived cells implicated in wound healing. Here, the authors utilise single cell RNA-seq, genetic ablation and multiplexed imaging to identify a fibrocyte population in lung cancer models, and use human lung cancer coculture systems to highlight their potential to modulate microenvironmental niche and sensitivity to endothelin blockade.

Andreas Weigert
Xiang Zheng
Rajkumar Savai
ResearchOpen Access14 Oct 2022
Nature Communications

Volume: 13, P: 1-21
Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease

Mouse models show that myelin dysfunction and associated inflammation increase with age, which can promote amyloid-β deposition and therefore risk of developing Alzheimer’s disease.

Constanze Depp
Ting Sun
Klaus-Armin Nave
ResearchOpen Access31 May 2023
Nature

Volume: 618, P: 349-357
Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin

EPO treatment improves cognition, but underlying mechanisms were unknown. Here the authors describe a regulatory loop in which brain networks challenged by cognitive tasks drift into functional hypoxia that drives—via neuronal EPO synthesis—neurodifferentiation and dendritic spine formation.

Debia Wakhloo
Franziska Scharkowski
Hannelore Ehrenreich
ResearchOpen Access09 Mar 2020
Nature Communications

Volume: 11, P: 1-12
White matter integrity in mice requires continuous myelin synthesis at the inner tongue

Myelin is formed of proteins of long half-lives. The mechanisms of renewal of such a stable structure are unclear. Here, the authors show that myelin integrity requires continuous myelin synthesis at the inner tongue, contributing to the maintenance of a functional axon-myelin unit.

Martin Meschkat
Anna M. Steyer
Wiebke Möbius
ResearchOpen Access04 Mar 2022
Nature Communications

Volume: 13, P: 1-18
CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression

Ectonucleotidases associated to regulatory T cells are known modulators in the inflammatory environment. Here the authors describe CD8 T cell-derived extracellular vesicles bearing CD73 and suggest they function as an additional intrinsic modulator of immune responses.

Enja Schneider
Riekje Winzer
Eva Tolosa
ResearchOpen Access08 Oct 2021
Nature Communications

Volume: 12, P: 1-14
Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy

Studies on interferon-driven brain pathology have so far been hampered by the lack of appropriate animal models. Here the authors characterize RNASET2-deficient mice and show that neuroinflammation and brain atrophy are IFNAR1-dependent.

Matthias Kettwig
Katharina Ternka
Jutta Gärtner
ResearchOpen Access11 Nov 2021
Nature Communications

Volume: 12, P: 1-18
Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes

Celia M Kassmann
Corinna Lappe-Siefke
Klaus-Armin Nave
Research22 Jul 2007
Nature Genetics

Volume: 39, P: 969-976
Liquid exfoliation of solvent-stabilized few-layer black phosphorus for applications beyond electronics

While phosphorene is an exciting new 2D material, techniques to produce it in large quantities in a stable, processable form are lacking. Here, the authors achieve this using liquid phase exfoliation and demonstrate the resultant nanosheets to be useful in a number of applications.

Damien Hanlon
Claudia Backes
Jonathan N. Coleman
ResearchOpen Access15 Oct 2015
Nature Communications

Volume: 6, P: 1-11
Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes

Netrins are secreted guidance factors that promote axon outgrowth and orientation during nervous system development. Here the authors present structural and biological evidence that netrin-4 is not a guidance cue per se, but rather functions to modulate laminin-laminin interactions.

Raphael Reuten
Trushar R. Patel
Manuel Koch
ResearchOpen Access30 Nov 2016
Nature Communications

Volume: 7, P: 1-17
Confirmation of the topology of the Wendelstein 7-X magnetic field to better than 1:100,000

Early stellarator designs suffered from high particle losses, an issue that can be addressed by optimization of the coils. Here the authors measure the magnetic field lines in the Wendelstein 7-X stellarator, confirming that the complicated design of the superconducting coils has been realized successfully.

T. Sunn Pedersen
M. Otte
Sandor Zoletnik
ResearchOpen Access30 Nov 2016
Nature Communications

Volume: 7, P: 1-10
Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1

Crystal and electron cryo-tomography structures of Mgm1 from Chaetomium thermophilum reveal that Mgm1 forms bent tetramers, which further assemble into helical filaments on both positively and negatively curved membranes.

Katja Faelber
Lea Dietrich
Oliver Daumke
Research10 Jul 2019
Nature

Volume: 571, P: 429-433
Mechanisms of axonal support by oligodendrocyte-derived extracellular vesicles

Oligodendrocytes secrete extracellular vesicles, which deliver cargo to axons where they regulate key cellular processes. In this Review, Krämer-Albers and Werner discuss the mechanisms by which extracellular vesicles promote neuronal health and their potential to be utilized therapeutically.

Eva-Maria Krämer-Albers
Hauke B. Werner
Reviews31 May 2023
Nature Reviews Neuroscience

Volume: 24, P: 474-486
The transcriptome of mouse central nervous system myelin

Sudhir Thakurela
Angela Garding
Vijay K. Tiwari
ResearchOpen Access13 May 2016
Scientific Reports

Volume: 6, P: 1-12
Comparative analysis of nuclear and mitochondrial DNA from tissue and liquid biopsies of colorectal cancer patients

Anna Haupts
Anne Vogel
Nils Hartmann
ResearchOpen Access18 Aug 2021
Scientific Reports

Volume: 11, P: 1-17
Prediction of clinical outcome and biological characterization of neuroblastoma by expression profiling

Alexander Schramm
Johannes H Schulte
Angelika Eggert
Research15 Aug 2005
Oncogene

Volume: 24, P: 7902-7912

Search

Gtf2i-encoded transcription factor Tfii-i regulates myelination via Sox10 and Mbp regulatory elements

CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves

Oligodendrocyte–axon metabolic coupling is mediated by extracellular K⁺ and maintains axonal health

Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia

Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system

Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease

Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin

White matter integrity in mice requires continuous myelin synthesis at the inner tongue

CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression

Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy

Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes

Liquid exfoliation of solvent-stabilized few-layer black phosphorus for applications beyond electronics

Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes

Confirmation of the topology of the Wendelstein 7-X magnetic field to better than 1:100,000

Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1

Mechanisms of axonal support by oligodendrocyte-derived extracellular vesicles

The transcriptome of mouse central nervous system myelin

Comparative analysis of nuclear and mitochondrial DNA from tissue and liquid biopsies of colorectal cancer patients

Prediction of clinical outcome and biological characterization of neuroblastoma by expression profiling

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