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Showing 1–4 of 4 results
Advanced filters: Author: Hauke Clausen-Schaumann Clear advanced filters

  • The basement membrane stiffness is shown to be a more dominant determinant than pore size in regulating cancer cell invasion, metastasis formation and patient survival. This stiffness is now known to be affected by the ratio of netrin-4 to laminin, with more netrin-4 leading to softer basement membranes.

    • Raphael Reuten
    • Sina Zendehroud
    • Janine T. Erler
    Research
    Nature Materials
    Volume: 20, P: 892-903

  • Netrins are secreted guidance factors that promote axon outgrowth and orientation during nervous system development. Here the authors present structural and biological evidence that netrin-4 is not a guidance cue per se, but rather functions to modulate laminin-laminin interactions.

    • Raphael Reuten
    • Trushar R. Patel
    • Manuel Koch
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-17

  • Atomic force microscopy can be used to determine the stiffness of materials. This protocol describes how to measure and quantify the Young’s modulus E of pulmonary mouse and human basement membranes with atomic force microscopy and the Center for Applied Tissue Engineering and Regenerative Medicine processing toolbox.

    • Bastian Hartmann
    • Lutz Fleischhauer
    • Raphael Reuten
    Protocols
    Nature Protocols
    Volume: 19, P: 1498-1528