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Showing 1–9 of 9 results
Advanced filters: Author: Hayden C. Metsky Clear advanced filters

  • One hundred and ten Zika virus genomes from ten countries and territories involved in the Zika virus epidemic reveal rapid expansion of the epidemic within Brazil and multiple introductions to other regions.

    • Hayden C. Metsky
    • Christian B. Matranga
    • Pardis C. Sabeti
    Research
    Nature
    Volume: 546, P: 411-415

  • CRISPR-based nucleic acid detection is used in a platform that can simultaneously detect 169 human-associated viruses in multiple samples, providing scalable, multiplexed pathogen detection aimed at routine surveillance for public health.

    • Cheri M. Ackerman
    • Cameron Myhrvold
    • Pardis C. Sabeti
    ResearchOpen Access
    Nature
    Volume: 582, P: 277-282

  • Viral diagnostics with maximum sensitivity are designed using machine learning and combinatorial optimization.

    • Hayden C. Metsky
    • Nicole L. Welch
    • Pardis C. Sabeti
    ResearchOpen Access
    Nature Biotechnology
    Volume: 40, P: 1123-1131

  • This study describes the integrative analysis of 111 reference human epigenomes, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression; the results annotate candidate regulatory elements in diverse tissues and cell types, their candidate regulators, and the set of human traits for which they show genetic variant enrichment, providing a resource for interpreting the molecular basis of human disease.

    • Anshul Kundaje
    • Wouter Meuleman
    • Manolis Kellis
    ResearchOpen Access
    Nature
    Volume: 518, P: 317-330