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Showing 1–4 of 4 results

Advanced filters: Author: Hayden Weng-Siong Tan Clear advanced filters

A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery

The mechanisms underlying mitochondrial quality control are not fully understood. Here the authors identify a switch from degradative to secretory autophagy in the absence of the mATG8-conjugation system, termed Autophagic Secretion of Mitochondria.

Hayden Weng Siong Tan
Guang Lu
Han-Ming Shen
ResearchOpen Access28 Jun 2022
Nature Communications

Volume: 13, P: 1-17
Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation

mTORC1 is a critical kinase that regulates cell growth and proliferation. Here the authors show that glutamine metabolism is sufficient to restore mTORC1 activity during prolonged amino acid starvation in an autophagy-dependent manner.

Hayden Weng Siong Tan
Arthur Yi Loong Sim
Yun Chau Long
ResearchOpen Access24 Aug 2017
Nature Communications

Volume: 8, P: 1-10
Author Correction: PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1–Parkin-mediated mitophagy

Liming Wang
Yik-Lam Cho
Han-Ming Shen
Amendments and Corrections23 Jul 2018
Cell Research

Volume: 28, P: 872-873
PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1–Parkin-mediated mitophagy

Liming Wang
Yik-Lam Cho
Han-Ming Shen
ResearchOpen Access22 Jun 2018
Cell Research

Volume: 28, P: 787-802