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Cell Death and Differentiation (1)
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Advanced filters: Author: Hayley I. Muendlein Clear advanced filters

ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1

Yersiania YopJ protein has been shown to drive caspase-8-mediated pyroptosis. Here the authors show a precise mechanism of this non-canonical cell death pathway that is controlled by a TRIF-dependent complex of FADD, RIPK1, caspase-8 and ZBP1.

Hayley I. Muendlein
Wilson M. Connolly
Alexander Poltorak
ResearchOpen Access04 Jan 2021
Nature Communications

Volume: 12, P: 1-13
Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis

Joseph Sarhan
Beiyun C. Liu
Alexander Poltorak
ResearchOpen Access21 May 2018
Cell Death & Differentiation

Volume: 26, P: 332-347

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ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1

Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis

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