This study shows that the transcription factor ZBTB46 is expressed in arterial endothelial cells, is regulated by shear stress and cell confluence. ZBTB46 inhibits endothelial cell proliferation through regulation of cell cycle genes, culminating in G0/G1 arrest, and decreased tube formation in an in vitro model of angiogenesis.
- Yu Wang
- He-Ying Sun
- Amir Rezvan
